Percorrer por autor "Carvalho, Patrícia"
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- DICIONÁRIO LÚDICO LUSO-BRASILEIROPublication . Carvalho, Patrícia; Viana, MarianaO “Dicionário Lúdico Luso-Brasileiro” trata-se de um projeto que possui como principal objetivo integrar e facilitar a comunicação verbal entre Portugal e Brasil, apontando as diferenças de algumas palavras usadas em cada país. Para romper a sobriedade do texto, o dicionário apresenta ilustrações que descrevem cenas específicas, divididas por temas, nas quais possam estar inseridas as palavras, porém sem legendas, para despertar a curiosidade do leitor. O relatório de Projeto Final do Mestrado em Ilustração Artística integra as referências artísticas, a descrição do processo criativo e as pesquisas realizadas até à execução do projeto prático
- Formação de conjuntos em educação pré-escolar : uma primeira experiência, um ponto de partidaPublication . Duque, Isabel; Pinho, Luana; Carvalho, Patrícia; Coelho, Ana; Vale, Vera; M. L. Martins, FernandoAs crianças devem ter oportunidade para desenvolver aprendizagens matemáticas, devendo a promoção desses momentos, na Educação Pré-Escolar (EPE), estar relacionada com o contexto e de acordo com os seus interesses. Sabemos que um dos objetivos da educação em Estatística, nesta etapa, está relacionado, ainda que de modo implícito, com a promoção da literacia estatística, que envolve a recolha e organização de dados (ME, 1997, 2010). Neste texto vamos apresentar a realização de uma experiência na qual a abordagem aos conteúdos da estatística foi feita por meio da metodologia de trabalho de projeto. Com base nos dados recolhidos durante a experiência pretendemos compreender as potencialidades de conciliar a metodologia de trabalho de projeto e os conhecimentos de um(a) educador(a) nas aprendizagens das crianças. Alguns resultados preliminares evidenciam que o contexto transdisciplinar associado aos conhecimentos estatísticos de um(a) educador(a) são determinantes para a promoção da literacia estatística e do raciocínio estatístico nas crianças.
- HIV-1 Diversity, Transmission Dynamics and Primary Drug Resistance in AngolaPublication . Bártolo, Inês; Zakovic, Susana; Martin, Francisco; Palladino, Claudia; Carvalho, Patrícia; Camacho, Ricardo; Thamm, Sven; Clemente, Sofia; Taveira, Nuno"Objectives: To assess HIV-1 diversity, transmission dynamics and prevalence of transmitted drug resistance (TDR) in Angola, five years after ART scale-up. Methods: Population sequencing of the pol gene was performed on 139 plasma samples collected in 2009 from drug-naive HIV-1 infected individuals living in Luanda. HIV-1 subtypes were determined using phylogenetic analysis. Drug resistance mutations were identified using the Calibrated Population Resistance Tool (CPR). Transmission networks were determined using phylogenetic analysis of all Angolan sequences present in the databases. Evolutionary trends were determined by comparison with a similar survey performed in 2001. Results: 47.1% of the viruses were pure subtypes (all except B), 47.1% were recombinants and 5.8% were untypable. The prevalence of subtype A decreased significantly from 2001 to 2009 (40.0% to 10.8%, P50.0019) while the prevalence of unique recombinant forms (URFs) increased.2-fold (40.0% to 83.1%, P,0.0001). The most frequent URFs comprised untypable sequences with subtypes H (U/H, n57, 10.8%), A (U/A, n56, 9.2%) and G (G/U, n54, 6.2%). Newly identified U/H recombinants formed a highly supported monophyletic cluster suggesting a local and common origin. TDR mutation K103N was found in one (0.7%) patient (1.6% in 2001). Out of the 364 sequences sampled for transmission network analysis, 130 (35.7%) were part of a transmission network. Forty eight transmission clusters were identified; the majority (56.3%) comprised sequences sampled in 2008–2010 in Luanda which is consistent with a locally fuelled epidemic. Very low genetic distance was found in 27 transmission pairs sampled in the same year, suggesting recent transmission events. Conclusions: Transmission of drug resistant strains was still negligible in Luanda in 2009, five years after the scale-up of ART. The dominance of small and recent transmission clusters and the emergence of new URFs are consistent with a rising HIV-1 epidemics mainly driven by heterosexual transmission."
- Predictors of attrition and immunological failure in HIV- 1 patients on highly active antiretroviral therapy from different healthcare settings in MozambiquePublication . Palladino, Claudia; Briz, Verónica; Bellón, José María; Bártolo, Inês; Carvalho, Patrícia; Camacho, Ricardo; Munõz-Fernandes, M. Ángeles; Bastos, Rui; Manuel, Rolanda; Casanovas, José; Taveira, Nuno"In Mozambique, the evaluation of retention in HIV care and ART programmes is limited. To assess rate and predictors of attrition (no retention in care) and HAART effectiveness in HIV-1 infected patients who pay for medication and laboratory testing in Mozambique, we conducted a multicenter survey of HIV-1-infected patients who started HAART during 2002– 2006. Cox proportional hazard models were used to assess risk of attrition and of therapy failure. Overall, 142 patients from 16 healthcare centers located in the capital city Maputo were followed-up for 22.2 months (12.1–46.7). The retention rate was 75%, 48% and 37% after one, two and three years, respectively. Risk of attrition was lower in patients with higher baseline CD4 count (P = 0.022) and attending healthcare center 1 (HCC1) (P = 0.013). The proportion of individuals with CD4 count #200 cells/mL was 55% (78/142) at baseline and decreased to 6% (3/52) at 36 months. Among the patients with available VL, 86% (64/74) achieved undetectable VL levels. The rate of immunologic failure was 17.2% (95% CI: 12.6–22.9) per 100 person-years. Risk of failure was associated to higher baseline CD4 count (P = 0.002), likely reflecting low adherence levels, and decreased with baseline VL $10,000 copies/mL (P = 0.033). These results suggest that HAART can be effective in HIV-1 infected patients from Mozambique that pay for their medication and laboratory testing. Further studies are required to identify the causes for low retention rates in patients with low CD4 counts and to better understand the association between healthcare setting and attrition rate."