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Publication
Dosagem e estabilidade de formas farmacêuticas fracionadas : revisão
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| 1.24 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Introdução: O fracionamento de comprimidos é uma prática frequente para obter a dose
prescrita, facilitar a deglutição ou reduzir custos. No entanto, esta prática pode ter impacto
clínico, afectando a efectividade e segurança do medicamento. Antes de se proceder ao
fracionamento de comprimidos devem ser considerados factores relacionados com o
medicamento, com características do fármaco, e factores relacionados com o utente, como
aceitabilidade e possível impacto na adesão à terapêutica.
Objetivo: Com esta revisão pretende-se abordar implicações na estabilidade e falta de
uniformidade de comprimidos fracionados, bem como os diversos fatores associados.
Material e Métodos: Este Trabalho de Projecto Original é uma revisão da literatura acerca da
Estabilidade e dosagem de formas farmacêuticas fracionadas, efectuada no período de dezembro
de 2019 a junho 2021. Neste estudo foram utilizadas fontes de informação primárias e
secundárias para a recolha de informação.
Resultados: A análise da literatura indica que a decisão de fracionar um comprimido deve ser
tomada caso a caso, após consulta do resumo das características do medicamento ou do
laboratório produtor e da avaliação do utente. Após recomendar este processo, importa
monitorizar aspectos como a segurança e efectividade do medicamento e a experiência do utente
com o procedimento. A maioria dos estudos associados ao fracionamento indica que apesar de se
verificarem flutuações no peso/dosagem dos comprimidos, estas habitualmente não têm impacto
no resultado clínico.
Conclusão: Ainda existem lacunas do conhecimento em relação ao fracionamento, havendo
alguma controvérsia em relação ao tema, entre o fraccionamento de comprimidos e avaliação da
uniformidade da dose e adesão à terapêutica. É desejável a realização de mais investigação com
vista a determinar a influência destes fatores de forma mais inequívoca.
Introduction: Pill splitting is a frequent practice to obtain the prescribed dose, to facilitate swallowing or to reduce costs. However, this practice can have a clinical impact, affecting the effectiveness and safety of the drug. Before doing it, you need to consider factors related to the drug such as characteristics of the drug and factors related to the user, such as acceptability and possible impact on the adherence to therapy. Objective: This review intends to address implications on stability and lack of uniformity of pill splitting, as well as the various associated factors. Methods: This Work is a Literature Review on the stability and dosage of fractionated pharmaceutical forms, carried out from December 2019 to June 2021. In this study, primary and secondary sources of information were used to collect information. Results: Research analysis indicates that the decision to split a pill should be taken on a case-by- case basis, after consulting the summary of the product's characteristics or the manufacturer's laboratory and assessing the user. After recommending this process, it is important to monitor aspects such as the safety and effectiveness of the drug and the user's experience with the procedure. Most studies associated with pill splitting indicate that although there are fluctuations in pill weight/dosage, these usually have no impact on clinical outcome. Conclusion: There are still gaps in knowledge regarding pill splitting, with some controversy regarding the topic, between the pill splitting and assessment of dose uniformity and adherence to medication. Further research is desirable to determine the influence of these factors more unequivocally.
Introduction: Pill splitting is a frequent practice to obtain the prescribed dose, to facilitate swallowing or to reduce costs. However, this practice can have a clinical impact, affecting the effectiveness and safety of the drug. Before doing it, you need to consider factors related to the drug such as characteristics of the drug and factors related to the user, such as acceptability and possible impact on the adherence to therapy. Objective: This review intends to address implications on stability and lack of uniformity of pill splitting, as well as the various associated factors. Methods: This Work is a Literature Review on the stability and dosage of fractionated pharmaceutical forms, carried out from December 2019 to June 2021. In this study, primary and secondary sources of information were used to collect information. Results: Research analysis indicates that the decision to split a pill should be taken on a case-by- case basis, after consulting the summary of the product's characteristics or the manufacturer's laboratory and assessing the user. After recommending this process, it is important to monitor aspects such as the safety and effectiveness of the drug and the user's experience with the procedure. Most studies associated with pill splitting indicate that although there are fluctuations in pill weight/dosage, these usually have no impact on clinical outcome. Conclusion: There are still gaps in knowledge regarding pill splitting, with some controversy regarding the topic, between the pill splitting and assessment of dose uniformity and adherence to medication. Further research is desirable to determine the influence of these factors more unequivocally.
Description
Keywords
Fracionamento de comprimidos Uniformidade de massa Linha de marcação Estabilidade de medicamentos Adesão à medicação