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Publication
Associação entre disfunção hepática e a periodontite
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| 2.44 MB | Adobe PDF |
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Abstract(s)
A disfunção hepática compreende um conjunto de patologias capazes de lesar e alterar a função normal do fígado, nomeadamente a cirrose hepática, hepatite viral, carcinoma hepatocelular, doença hepática gordurosa não alcoólica, entre outras. Uma vez que existe um comprometimento do sistema imunitário e um aumento da suscetibilidade do indivíduo, verificou-se que pacientes com disfunção hepática possuem um estado de saúde periodontal alterado.
A periodontite é considerada uma doença infeto-inflamatória crónica que provoca a destruição das estruturas de suporte do dente, sendo das patologias mais prevalentes na população adulta com elevadas repercussões na saúde oral e sistémica.Estudos científicos sugerem a participação da doença periodontal na progressão de patologias hepáticas, referindo a associação de determinados mecanismos, principalmente bactérias, mediadores pro-inflamatórios e o stress oxidativo, sendo estes os possíveis responsáveis pelo papel da periodontite em doenças hepáticas. De facto, fatores como a natureza inflamatória de ambas as patologias, os fatores psicológicos associados a doentes hepáticos, acompanhados de uma má higienização oral, o aumento do crescimento bacteriano periodontal, devido à reduzida função por parte do fígado na eliminação de bactérias e produtos tóxicos ao organismo são também tomados em consideração como possíveis mecanismos implicados nesta relação/associação.
Em suma, pretende-se com esta monografia analisar a possível relação entre a periodontite e a disfunção hepática.
Liver dysfunction comprises a range of pathologies capable of damaging and altering normal liver function, including liver cirrhosis, viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver disease (steatosis), among others. Since there is a compromised immune system and increased susceptibility of the individual, it has been found that patients with liver dysfunction have an altered periodontal health status. Periodontitis is considered a chronic infection-inflammatory disease that causes the destruction of tooth support structures and it is one of the most prevalent pathologies in the adult population with high oral and systemic health repercussions.Scientific studies suggest the participation of periodontal disease in the progression of hepatic pathologies, referring to the association of certain mechanisms, mainly bacteria, pro-inflammatory mediators and oxidative stress, these being the possible responsible for the role of periodontitis in hepatic diseases. In fact, factors such as the inflammatory nature of both pathologies, psychological factors associated with liver patients, accompanied by poor oral hygiene, increased periodontal bacterial growth due to reduced function by the liver in eliminating bacteria and toxic products to the body are also taken into account as possible mechanisms involved in this relationship/association. In short, this monograph aims to analyze the possible relationship between periodontitis and liver dysfunctions.
Liver dysfunction comprises a range of pathologies capable of damaging and altering normal liver function, including liver cirrhosis, viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver disease (steatosis), among others. Since there is a compromised immune system and increased susceptibility of the individual, it has been found that patients with liver dysfunction have an altered periodontal health status. Periodontitis is considered a chronic infection-inflammatory disease that causes the destruction of tooth support structures and it is one of the most prevalent pathologies in the adult population with high oral and systemic health repercussions.Scientific studies suggest the participation of periodontal disease in the progression of hepatic pathologies, referring to the association of certain mechanisms, mainly bacteria, pro-inflammatory mediators and oxidative stress, these being the possible responsible for the role of periodontitis in hepatic diseases. In fact, factors such as the inflammatory nature of both pathologies, psychological factors associated with liver patients, accompanied by poor oral hygiene, increased periodontal bacterial growth due to reduced function by the liver in eliminating bacteria and toxic products to the body are also taken into account as possible mechanisms involved in this relationship/association. In short, this monograph aims to analyze the possible relationship between periodontitis and liver dysfunctions.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Disfunção hepática Doenças hepáticas crónicas Doença periodontal Periodontite