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Publication
Bioprinting 3D : uma alternativa à experimentação animal em farmacotoxicologia
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Abstract(s)
Modelos animais têm sido utilizados em ensaios experimentais com o objetivo de aumentar o conhecimento que se tem acerca de potenciais fármacos e contribuir para encontrar respostas para questões biológicas e biomédicas que vão surgindo. No entanto, urge uma preocupação com o bem-estar dos animais utilizados nestes ensaios, e a crescente consciência do conceito “Direitos dos Animais” veio aumentar o foco sobre questões éticas.
Os modelos animais são, ao momento, considerados inadequados para fazer uma previsão fiel da toxicidade e eficácia dos fármacos a ser estudos, conduzindo a uma necessidade iminente da utilização de novas estratégias in vitro na fase pré-clínica com capacidade de representar melhor as condições in vivo e facilitar na investigação sistematizada de candidatos a novos medicamentos.
Os avanços recentes na bioimpressão 3D têm demonstrado a manipulação precisa de células e biomateriais, tornando-a uma tecnologia promissora na construção de modelos in vitro de tecidos/órgãos e dispositivos na triagem de medicamentos.
Modelos in vitro de tecidos/órgãos são plataformas úteis com potencial para facilitar ensaios clínicos na descoberta e desenvolvimento de fármacos. O objetivo principal ao desenvolver modelos tridimensionais é reproduzir funções fisiologicamente relevantes que normalmente requerem sistemas mais complexos. Tecidos/órgãos bioimpressos revelam grande potencial na triagem de novos compostos ou em estudos de toxicidade, já que a complexidade espacial e química inerente a tecidos e órgãos nativos pode ser recriada.
Animal models have been used in experimental trials to increase knowledge about potential drugs and help to find answers to emerging biological and biomedical questions. However, a concern for the welfare of the animals used in these trials is urgent, and the growing awareness of the concept "Animal Rights" has increased the focus on ethical issues. Animal models are currently considered inadequate to accurately predict the toxicity and efficacy of the drugs to be studied, leading to an imminent need for the use of new in vitro strategies in the pre-clinical phase with the capacity to better represent in vivo conditions and facilitate systematic research of candidates for new drugs. Recent advances in 3D bioprinting have demonstrated the precise manipulation of cells and biomaterials, making it a promising technology for building in vitro models of tissues/organs and devices in drug screening. In vitro tissue/organism models are useful platforms with the potential to facilitate clinical trials in drug discovery and development. The main objective in developing three-dimensional models is to reproduce physiologically relevant functions that normally require more complex systems. Bioprinted tissues/organs show great potential in screening new compounds or in toxicity studies, as the spatial and chemical complexity inherent in native tissues and organs can be recreated.
Animal models have been used in experimental trials to increase knowledge about potential drugs and help to find answers to emerging biological and biomedical questions. However, a concern for the welfare of the animals used in these trials is urgent, and the growing awareness of the concept "Animal Rights" has increased the focus on ethical issues. Animal models are currently considered inadequate to accurately predict the toxicity and efficacy of the drugs to be studied, leading to an imminent need for the use of new in vitro strategies in the pre-clinical phase with the capacity to better represent in vivo conditions and facilitate systematic research of candidates for new drugs. Recent advances in 3D bioprinting have demonstrated the precise manipulation of cells and biomaterials, making it a promising technology for building in vitro models of tissues/organs and devices in drug screening. In vitro tissue/organism models are useful platforms with the potential to facilitate clinical trials in drug discovery and development. The main objective in developing three-dimensional models is to reproduce physiologically relevant functions that normally require more complex systems. Bioprinted tissues/organs show great potential in screening new compounds or in toxicity studies, as the spatial and chemical complexity inherent in native tissues and organs can be recreated.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Bioimpressão 3D Toxicidade Experimentação animal Alternativa