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CaracterizaĆ§Ć£o da antibioterapia no idoso
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Abstract(s)
A nĆvel mundial, verifica-se um aumento da populaĆ§Ć£o idosa, devido Ć crescente esperanƧa de vida e Ć diminuiĆ§Ć£o da taxa de natalidade. Associada Ć idade avanƧada, diversas alteraƧƵes, tanto a nĆvel fisiolĆ³gico, como psicolĆ³gico e social ocorrem no idoso.
As modificaƧƵes derivadas do envelhecimento contribuem para o desenvolvimento e aparecimento de comorbilidades, bem como para o aumento do nĆŗmero de medicamentos consumidos. Em virtude destas alteraƧƵes, o doente geriĆ”trico apresenta-se como um indivĆduo complexo. A resposta farmacocinĆ©tica/farmacodinĆ¢mica dos fĆ”rmacos pode-se encontrar alterada, contribuindo para um risco superior de reaƧƵes adversas e interaƧƵes medicamentosas quando comparada com a populaĆ§Ć£o mais jovem. Adicionalmente, a necessidade de realizar antibioterapia Ć© superior devido Ć maior suscetibilidade a infeƧƵes nesta faixa etĆ”ria.
A instituiĆ§Ć£o da terapĆŖutica antibiĆ³tica no idoso Ć© um processo complexo. O diagnĆ³stico, a presenƧa de mĆŗltiplas patologias e diversas medicaƧƵes, as alteraƧƵes naturais do envelhecimento e o maior risco de desenvolvimento de resistĆŖncias sĆ£o fatores que contribuem para aumentar a dificuldade no processo de decisĆ£o. Assim, a gestĆ£o da terapĆŖutica antibiĆ³tica no idoso deve contemplar inĆŗmeros fatores, baseando-se no perfil individual de cada doente, garantindo a efetividade e a seguranƧa do tratamento, de modo a prevenir futuras complicaƧƵes.
Globally, the elderly population is increasing due to the rising life expectancy and declining birth rates. Associated with advanced age, several changes, both physiological, psychological and social occur in the elderly. Modifications derived from aging contribute to the development of comorbidities, as well as to the increase in the number of drugs consumed. Due to these changes, the geriatric patient is presented as a complex individual. The pharmacokinetic/pharmacodynamic response of drugs may be altered, contributing to a higher risk of adverse reactions and drug interactions compared to the younger population. Additionally, the need for antibiotic therapy is higher due to greater susceptibility to infections in this age group. The institution of antibiotic therapy in the elderly is a challenging process due to the difficulty in diagnosis, the presence of multiple pathologies and polipharmacy, the natural changes in aging and the increased risk of resistance development. Thus, the management of antibiotic therapy in the elderly should consider multiple factors, based on the individual profile of each patient, ensuring the effectiveness and safety of treatment, in order to prevent future complications.
Globally, the elderly population is increasing due to the rising life expectancy and declining birth rates. Associated with advanced age, several changes, both physiological, psychological and social occur in the elderly. Modifications derived from aging contribute to the development of comorbidities, as well as to the increase in the number of drugs consumed. Due to these changes, the geriatric patient is presented as a complex individual. The pharmacokinetic/pharmacodynamic response of drugs may be altered, contributing to a higher risk of adverse reactions and drug interactions compared to the younger population. Additionally, the need for antibiotic therapy is higher due to greater susceptibility to infections in this age group. The institution of antibiotic therapy in the elderly is a challenging process due to the difficulty in diagnosis, the presence of multiple pathologies and polipharmacy, the natural changes in aging and the increased risk of resistance development. Thus, the management of antibiotic therapy in the elderly should consider multiple factors, based on the individual profile of each patient, ensuring the effectiveness and safety of treatment, in order to prevent future complications.
Description
DissertaĆ§Ć£o para obtenĆ§Ć£o do grau de Mestre no Instituto UniversitĆ”rio Egas Moniz
Keywords
Envelhecimento Antibioterapia Idoso InfeƧƵes bacterianas