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Challenges and (Un)Certainties for DNAm Age Estimation in Future
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Orientador(es)
Resumo(s)
Age estimation is a paramount issue in criminal, anthropological, and forensic research.
Because of this, several areas of research have focused on the establishment of new approaches for age
prediction, including bimolecular and anthropological methods. In recent years, DNA methylation
(DNAm) has arisen as one of the hottest topics in the field. Many studies have developed age-
prediction models (APMs) based on evaluation of DNAm levels of many genes in different tissue
types and using different methodological approaches. However, several challenges and confounder
factors should be considered before using methylation levels for age estimation in forensic contexts.
To provide in-depth knowledge about DNAm age estimation (DNAm age) and to understand why it
is not yet a current tool in forensic laboratories, this review encompasses the literature for the most
relevant scientific works published from 2015 to 2021 to address the challenges and future directions
in the field. More than 60 papers were considered focusing essentially on studies that developed
models for age prediction in several sample types
Descrição
Palavras-chave
Forensic Science Age estimation DNA Methylation Epigenetic age estimation
Contexto Educativo
Citação
Correia Dias, H., Cunha, E., Corte Real, F., & Manco, L. (2022). Challenges and (Un)Certainties for DNAm Age Estimation in Future. Forensic Sciences, 2(3), 601–614
Editora
MDPI