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Histomorphometric evaluation of the small coronary arteries in rats exposed to industrial noise

2015-05Journal article Open access
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dc.contributor.authorLousinha, Ana
dc.contributor.authorAntunes, Eduardo
dc.contributor.authorBorrecho, Gonçalo
dc.contributor.authorOliveira, Maria João
dc.contributor.authorBrito, José
dc.contributor.authorMartins dos Santos, José
dc.date.accessioned2017-05-29T10:45:46Z
dc.date.available2017-05-29T10:45:46Z
dc.date.issued2015-05
dc.description.abstractMorphological changes induced by industrial noise (IN) have been experimentally observed in several organs. Histological observations of the coronary arteries showed prominent perivascular tissue and fibrosis among IN-exposed rats. The effects on the small arteries are unknown. Objective: To evaluate the histomorphometric changes induced by IN on rat heart small arteries. Methods: Twenty Wistar rats exposed to IN during a maximum period of seven months and 20 age-matched controls were studied. Hearts were transversely sectioned from ventricular apex to atria and a mid-ventricular fragment was selected for analysis. The histological images were obtained with an optical microscope using 400× magnifications. A total of 634 arterial vessels (298 IN-exposed and 336 controls) were selected. The mean lumen-to-vessel wall (L/W) and mean vessel wall-to-perivascular tissue (W/P) ratios were calculated using image J software. Results: There were no differences between exposed and control animals in their L/W ratios (p = 0.687) and time variations in this ratio were non-significant (p = 0.110). In contrast, exposed animals showed lower W/P ratios than control animals (p < 0.001), with significant time variations (p = 0.004). Conclusions: Industrial noise induced an increase in the perivascular tissue of rat small coronary arteries, with significant development of periarterial fibrosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt. J. Mol. Sci. 2015, 16, 10095-10104; doi:10.3390/ijms160510095pt_PT
dc.identifier.doi10.3390/ijms160510095pt_PT
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.26/18414
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/1422-0067/16/5/10095pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIndustrial noisept_PT
dc.subjectSmall coronary arteriespt_PT
dc.subjectLow-frequency noisept_PT
dc.titleHistomorphometric evaluation of the small coronary arteries in rats exposed to industrial noisept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10104pt_PT
oaire.citation.startPage10095pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume16(5)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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