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Histomorphometric evaluation of the small coronary arteries in rats exposed to industrial noise
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Orientador(es)
Resumo(s)
Morphological changes induced by industrial noise (IN) have been
experimentally observed in several organs. Histological observations of the coronary
arteries showed prominent perivascular tissue and fibrosis among IN-exposed rats. The
effects on the small arteries are unknown. Objective: To evaluate the histomorphometric
changes induced by IN on rat heart small arteries. Methods: Twenty Wistar rats exposed to
IN during a maximum period of seven months and 20 age-matched controls were studied.
Hearts were transversely sectioned from ventricular apex to atria and a mid-ventricular
fragment was selected for analysis. The histological images were obtained with an optical
microscope using 400× magnifications. A total of 634 arterial vessels (298 IN-exposed
and 336 controls) were selected. The mean lumen-to-vessel wall (L/W) and mean vessel
wall-to-perivascular tissue (W/P) ratios were calculated using image J software. Results:
There were no differences between exposed and control animals in their L/W ratios
(p = 0.687) and time variations in this ratio were non-significant (p = 0.110). In contrast,
exposed animals showed lower W/P ratios than control animals (p < 0.001), with
significant time variations (p = 0.004). Conclusions: Industrial noise induced an increase in
the perivascular tissue of rat small coronary arteries, with significant development of
periarterial fibrosis.
Descrição
Palavras-chave
Industrial noise Small coronary arteries Low-frequency noise
Contexto Educativo
Citação
Int. J. Mol. Sci. 2015, 16, 10095-10104; doi:10.3390/ijms160510095
Editora
MDPI