Publication
Antibiotic therapy for the prevention of osteoradionecrosis following tooth extraction in head-and-neck cancer patients postradiotherapy : An 11-year retrospective study
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Palma, Luiz Felipe | |
| dc.contributor.author | Marcucci, Marcelo | |
| dc.contributor.author | Remondes, Cíntia Maria | |
| dc.contributor.author | Chambrone, Leandro | |
| dc.date.accessioned | 2025-09-09T10:06:02Z | |
| dc.date.available | 2025-09-09T10:06:02Z | |
| dc.date.issued | 2021-09 | |
| dc.description.abstract | Introduction: One of the most important complications of radiotherapy (RT) for head-and-neck cancer (HNC) is osteoradionecrosis (ORN) of the jaws, which mostly arises from tooth extractions. The ORN treatment still represents a great challenge; therefore, the prevention is of paramount importance. Thus, the present study aimed to evaluate retrospectively a perioperative systemic antibiotic therapy protocol for the prevention of ORN following tooth extraction in head-and-neck patients post-3D conformal RT. Materials and Methods: A retrospective medical record review was performed considering HNC patients submitted to RT in the period between 2008 and 2019. They necessarily received oral antibiotic therapy with Clindamycin 300 mg every 8 h for 10 days, with the first dose 3 days before the tooth extraction. Results: Forty-nine patients met the study criteria, with a total of 107 teeth extracted. Regarding the 47 patients who did not develop ORN, 103 tooth extractions were identified (96.3%). Only two patients developed ORN at two adjacent teeth sites (3.7%). Conclusion: The proposed perioperative systemic antibiotic therapy protocol seems to be efficient to prevent ORN following tooth extraction in postirradiated HNC patients. | eng |
| dc.identifier.citation | PALMA, LUIZ FELIPE; MARCUCCI, MARCELO; REMONDES, CíNTIA MARIA; CHAMBRONE, LEANDRO. Antibiotic therapy for the prevention of osteoradionecrosis following tooth extraction in head-and-neck cancer patients postradiotherapy: An 11-year retrospective study. National Journal of Maxillofacial Surgery 12(3):p 333-338, Sep–Dec 2021. | DOI: 10.4103/njms.njms_413_21 | |
| dc.identifier.doi | 10.4103/njms.njms_413_21 | |
| dc.identifier.issn | 0975-5950 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58625 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wolters Kluwer | |
| dc.relation.hasversion | https://doi.org/10.4103/njms.njms_413_21 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Head-and-neck cancer | |
| dc.subject | osteoradionecrosis | |
| dc.subject | radiotherapy | |
| dc.subject | tooth extraction | |
| dc.title | Antibiotic therapy for the prevention of osteoradionecrosis following tooth extraction in head-and-neck cancer patients postradiotherapy : An 11-year retrospective study | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 338 | |
| oaire.citation.issue | 3 | |
| oaire.citation.startPage | 333 | |
| oaire.citation.title | National Journal of Maxillofacial Surgery | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |