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Authors
Advisor(s)
Abstract(s)
Esta tese explora o processo de remineralização do esmalte e da dentina, essencial para prevenir e tratar cáries dentárias. Ela aborda a composição e a estrutura desses tecidos dentários, bem como os mecanismos de sua desmineralização, como erosão e cárie dentária.
A tese então se aprofunda em diferentes moléculas de remineralização, incluindo flúor, fosfopeptídeo de caseína-fosfato de cálcio amorfo (CPP-ACP), fosfato tricálcico (TCP), CSPS silicato de cálcio e fosfato de sódio (CSPS) e nanopartículas de hidroxiapatite (nHA). Os mecanismos de ação, aplicações comerciais e vantagens e desvantagens de cada molécula são detalhados.
Uma revisão da literatura compara a eficácia dessas moléculas, destacando os seus pontos fortes e fracos. A tese enfatiza a importância de escolher o produto de remineralização apropriado com base nas necessidades específicas do indivíduo e no contexto clínico do paciente, abrindo assim novas perspetivas para a remineralização do esmalte dentário e oferecendo esperança para uma melhor prevenção e tratamento mais eficaz da cárie dentária.
This thesis explores the process of enamel and dentin remineralization, which is essential for preventing and treating dental caries. It discusses the composition and structure of these dental tissues, as well as the mechanisms of their demineralization, such as erosion and dental caries. The thesis then delves into different remineralization molecules, including fluoride, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), tricalcium phosphate (TCP), calcium silicate and sodium phosphate (CSPS), and hydroxyapatite nanoparticles (nHA). The mechanisms of action, commercial applications, and advantages and disadvantages of each molecule are detailed. A literature review compares the effectiveness of these molecules, highlighting their respective strengths and weaknesses. The thesis emphasizes the importance of choosing the appropriate remineralization product based on the patient's specific needs and clinical context, thus opening new perspectives for enamel remineralization and offering hope for better prevention and more effective treatment of dental caries.
This thesis explores the process of enamel and dentin remineralization, which is essential for preventing and treating dental caries. It discusses the composition and structure of these dental tissues, as well as the mechanisms of their demineralization, such as erosion and dental caries. The thesis then delves into different remineralization molecules, including fluoride, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), tricalcium phosphate (TCP), calcium silicate and sodium phosphate (CSPS), and hydroxyapatite nanoparticles (nHA). The mechanisms of action, commercial applications, and advantages and disadvantages of each molecule are detailed. A literature review compares the effectiveness of these molecules, highlighting their respective strengths and weaknesses. The thesis emphasizes the importance of choosing the appropriate remineralization product based on the patient's specific needs and clinical context, thus opening new perspectives for enamel remineralization and offering hope for better prevention and more effective treatment of dental caries.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Remineralização Desmineralização CPP-ACP Flúor
