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Effect of aqueous cinnamon extract on the postprandial glycemia levels in patients with type 2 Diabetes mellitus : a randomized controlled trial

2022-04Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorRachid, Ana Paula
dc.contributor.authorMoncada, Margarida
dc.contributor.authorMesquita, Maria Fernanda de
dc.contributor.authorBrito, José
dc.contributor.authorBernardo, Maria Alexandra
dc.contributor.authorSilva, Maria Leonor
dc.date.accessioned2025-11-07T10:50:40Z
dc.date.available2025-11-07T10:50:40Z
dc.date.issued2022-04
dc.description.abstractCinnamon is a spice used in traditional cuisine that has been investigated due to hypoglycemic properties. The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mellitus (DM2) adults. This clinical trial enrolled 36 adults with DM2, randomly allocated in two groups: the control group (n = 18) took only an oral glucose tolerance test (OGTT) and the intervention group (n = 18) took OGTT immediately followed by aqueous cinnamon extract (6 g/100 mL) ingestion. Blood glucose levels were measured on fasting and after 30, 60, 90 and 120 min in both groups. The chemical analysis of the aqueous cinnamon extract included total phenols content determination and antioxidant activity assessment through FRAP and DPPH methods. The data reveal that aqueous cinnamon extract ingestion did not show a significant difference in the incremental area under the curve (p = 0.834), maximum glucose concentration (p = 0.527) and glucose concentration variation (p = 0.873) compared with the control group. Cinnamon extract possess a total phenol content of 1554.9 mg/L gallic acid equivalent and a strong antioxidant capacity, revealed by the DPPH (5125.0 µmol Trolox/L) and FRAP (3658.8 µmol Trolox/L) tests. Aqueous cinnamon extract did not significantly influence postprandial glucose response in diabetic patients during an OGTT.eng
dc.identifier.citationRachid AP, Moncada M, Mesquita MFd, Brito J, Bernardo MA, Silva ML. Effect of Aqueous Cinnamon Extract on the Postprandial Glycemia Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Nutrients. 2022; 14(8):1576. https://doi.org/10.3390/nu14081576
dc.identifier.doi10.3390/nu14081576
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.26/59550
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/nu14081576
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCinnamomum burmannii
dc.subjectcinnamon
dc.subjectpostprandial glycaemia
dc.subjecttype 2 diabetes mellitus
dc.subjectantioxidant
dc.subjectpolyphenols
dc.titleEffect of aqueous cinnamon extract on the postprandial glycemia levels in patients with type 2 Diabetes mellitus : a randomized controlled trialeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.startPage1576
oaire.citation.titleNutrients
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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