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HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study

2019-04Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLópez-Huertas, Maria Rosa
dc.contributor.authorPalladino, Claudia
dc.contributor.authorGarrido-Arquero, Marta
dc.contributor.authorEsteban-Cartelle, Beatriz
dc.contributor.authorSánchez-Carrillo, Marta
dc.contributor.authorMartínez-Román, Paula
dc.contributor.authorMartín-Carbonero, Luz
dc.contributor.authorRyan, Pablo
dc.contributor.authorDomínguez-Domínguez, Lourdes
dc.contributor.authorDe Los Santos, Ignacio
dc.contributor.authorDe La Fuente Moral, Sara
dc.contributor.authorBenito, José Miguel
dc.contributor.authorRallón, Norma
dc.contributor.authorAlcamí, José
dc.contributor.authorResino, Salvador
dc.contributor.authorFernández-Rodríguez, Amanda
dc.contributor.authorCoiras, Mayte
dc.contributor.authorBriz, Verónica
dc.contributor.authorMultidisciplinary Group of viral coinfection HIV/Hepatitis (COVIHEP)
dc.date.accessioned2025-07-16T09:42:17Z
dc.date.available2025-07-16T09:42:17Z
dc.date.issued2019-04
dc.description.abstractIn HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32 HIV patients with HCV spontaneous clearance and 29 HIV-monoinfected patients. rCD4+ T-cells were isolated and total DNA was extracted. HIV viral reservoir was measured by Alu-LTR qPCR. Differences between groups were calculated with a generalized linear model. Overall, 63.9% were men, median age of 41 years and Caucasian. Median CD4+ and CD8+ T-lymphocytes were 725 and 858 cells/mm3, respectively. CD4+ T nadir cells was 305 cells/mm3. Proviral HIV-1 DNA size was significantly increased in chronic HIV/HCV-coinfected compared to HIV-monoinfected patients (206.21 ± 47.38 vs. 87.34 ± 22.46, respectively; P = 0.009), as well as in spontaneously clarified HCV co-infected patients when compared to HIV-monoinfected individuals (136.20 ± 33.20; P = 0.009). HIV-1/HCV co-infected patients showed a larger HIV-1 reservoir size in comparison to HIV-monoinfected individuals. This increase could lead to a greater complexity in the elimination of HIV-1 reservoir in HIV-1/HCV-coinfected individuals, which should be considered in the current strategies for the elimination of HIV-1 reservoir.eng
dc.identifier.citationLópez-Huertas, M.R., Palladino, C., Garrido-Arquero, M. et al. HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study. Sci Rep 9, 5606 (2019). https://doi.org/10.1038/s41598-019-41788-9
dc.identifier.doi10.1038/s41598-019-41788-9
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.26/58080
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://doi.org/10.1038/s41598-019-41788-9
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleHCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional studyeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage5606
oaire.citation.titleScientific Reports
oaire.citation.volume9
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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