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A contribuição das células estaminais do ligamento periodontal numa óptica de regeneração dos tecidos, uma revisão integrativa dos estudos in vivo
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Authors
Abstract(s)
Introdução: O início da engenharia de tecidos a partir dos anos 2000 abriu novas possibilidades no tratamento de várias doenças. Infelizmente, estas tecnologias ainda têm limitações, mas a identificação de células estaminais do ligamento periodontal, nos vários estudos desenvolvidos em engenharia tecidual mostram que é possível regenerar tecidos danificados pela periodontite. Nos últimos anos, muitos tratamentos têm sido
desenvolvidos em engenharia de tecidos com o objetivo de regenerar danos teciduais causados pela periodontite.
Objetivos: O objetivo final desta revisão integrativa (RI) é avaliar o potencial terapêutico e clínico das células estaminais do ligamento periodontal para tratamentos futuros da periodontite.
Materiais e Métodos: Nesta revisão narrativa foram utilizadas 3 bases de dados digitais PubMed, Web of Science, Cochrane para selecionar os estudos em que foram transplantadas células estaminais do ligamento periodontal para áreas com defeitos tecidulares causados por periodontite. Utilizando a metodologia PICO sintetizaram-se os resultados de 12 artigos, 11 tratam da transplantação em animais e um da transplantação
em seres humanos.
Resultados: A análise de 12 estudos mostra após o transplante, uma melhoria significativa na perda de inserção, e graças à análise histológica e tomográfica uma regeneração dos três principais tecidos do periodonto, ou seja, osso, ligamento periodontal e cemento contribuindo para a restauração da inserção periodontal, sem quaisquer efeitos adversos.
Conclusões: Esta revisão integrativa destaca o potencial significativo das células estaminais do ligamento periodontal para a regeneração periodontal. Os resultados atuais ainda exigem uma investigação mais aprofundada. Estudos clínicos maiores e de longo prazo são necessários para avaliar melhor a eficácia e a segurança desta abordagem regenerativa.
Introduction: The beginning of tissue engineering in the 2000s opened up new possibilities in the treatment of various diseases. Unfortunately, these technologies still have limitations, but the identification of periodontal ligament stem cells in the various studies developed in tissue engineering show that it is possible to regenerate tissues damaged by periodontitis. In recent years, many treatments have been developed in tissue engineering with the aim of regenerating tissue damage caused by periodontitis. Objectives: The ultimate goal of this integrative review (IR) is to evaluate the therapeutic and clinical potential of periodontal ligament stem cells for future treatments of periodontitis. Materials and Methods: In this narrative revision, 3 digital databases PubMed, Web of Science, Cochrane were used to select studies in which periodontal ligament stem cells were transplanted into areas with tissue deficiencies caused by periodontitis. In this integrative review, the results of 12 articles are synthesized, 11 dealing with transplantation in animals and one with transplantation in humans. Results: The analysis of 12 studies shows after transplantation, a significant gain in the attachment loss, and thanks to the histological and tomographic analysis a regeneration of the three main tissues of the periodontium, bone, periodontal ligament and cementum contributing to the restoration of periodontal attachment, without any adverse effects. Conclusions: This integrative review highlights the significant potential of periodontal ligament stem cells for periodontal regeneration. The current results still require further investigation. Larger, long-term clinical studies are needed to better evaluate the efficacy and safety of this regenerative approach.
Introduction: The beginning of tissue engineering in the 2000s opened up new possibilities in the treatment of various diseases. Unfortunately, these technologies still have limitations, but the identification of periodontal ligament stem cells in the various studies developed in tissue engineering show that it is possible to regenerate tissues damaged by periodontitis. In recent years, many treatments have been developed in tissue engineering with the aim of regenerating tissue damage caused by periodontitis. Objectives: The ultimate goal of this integrative review (IR) is to evaluate the therapeutic and clinical potential of periodontal ligament stem cells for future treatments of periodontitis. Materials and Methods: In this narrative revision, 3 digital databases PubMed, Web of Science, Cochrane were used to select studies in which periodontal ligament stem cells were transplanted into areas with tissue deficiencies caused by periodontitis. In this integrative review, the results of 12 articles are synthesized, 11 dealing with transplantation in animals and one with transplantation in humans. Results: The analysis of 12 studies shows after transplantation, a significant gain in the attachment loss, and thanks to the histological and tomographic analysis a regeneration of the three main tissues of the periodontium, bone, periodontal ligament and cementum contributing to the restoration of periodontal attachment, without any adverse effects. Conclusions: This integrative review highlights the significant potential of periodontal ligament stem cells for periodontal regeneration. The current results still require further investigation. Larger, long-term clinical studies are needed to better evaluate the efficacy and safety of this regenerative approach.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Ligamento periodontal Transplante de células Células estaminais Periodontite