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Molecular epidemiology of HIV-1 infected migrants followed up in Portugal: trends between 2001–2017

2020-03Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPimentel, Victor
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAlves, Daniela
dc.contributor.authorDiogo, Isabel
dc.contributor.authorFernandes, Sandra
dc.contributor.authorMiranda, Mafalda
dc.contributor.authorPineda-Peña, Andrea-Clemencia
dc.contributor.authorLibin, Pieter
dc.contributor.authorMartins, M. Rosário O.
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorCamacho, Ricardo
dc.contributor.authorGomes, Perpétua
dc.contributor.authorAbecasis, Ana
dc.date.accessioned2025-07-28T10:52:34Z
dc.date.available2025-07-28T10:52:34Z
dc.date.issued2020-03
dc.description.abstractMigration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) and Nucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur.eng
dc.identifier.citationPimentel, V., Pingarilho, M., Alves, D., Diogo, I., Fernandes, S., Miranda, M., Pineda-Peña, A.-C., Libin, P., Martins, M. R. O., Vandamme, A.-M., Camacho, R., Gomes, P., & Abecasis, A. (2020). Molecular Epidemiology of HIV-1 Infected Migrants Followed Up in Portugal: Trends between 2001–2017. Viruses, 12(3), 268. https://doi.org/10.3390/v12030268
dc.identifier.doi10.3390/v12030268
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/10400.26/58207
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/v12030268
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMigrants
dc.subjectmolecular epidemiology
dc.subjectHIV drug resistance mutations
dc.titleMolecular epidemiology of HIV-1 infected migrants followed up in Portugal: trends between 2001–2017eng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPage268
oaire.citation.titleViruses
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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