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Molecular epidemiology of HIV-1 infected migrants followed up in Portugal: trends between 2001–2017

2020-03Contributo em revista Acesso aberto
http://hdl.handle.net/10400.26/58207
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Autores

Pimentel, Victor
Pingarilho, Marta
Alves, Daniela
Diogo, Isabel
Fernandes, Sandra
Miranda, Mafalda
Pineda-Peña, Andrea-Clemencia
Libin, Pieter
Martins, M. Rosário O.
Vandamme, Anne-Mieke

Orientador(es)

Resumo(s)

Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) and Nucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur.

Descrição

Palavras-chave

Migrants molecular epidemiology HIV drug resistance mutations

URI

http://hdl.handle.net/10400.26/58207

Contexto Educativo

Citação

Pimentel, V., Pingarilho, M., Alves, D., Diogo, I., Fernandes, S., Miranda, M., Pineda-Peña, A.-C., Libin, P., Martins, M. R. O., Vandamme, A.-M., Camacho, R., Gomes, P., & Abecasis, A. (2020). Molecular Epidemiology of HIV-1 Infected Migrants Followed Up in Portugal: Trends between 2001–2017. Viruses, 12(3), 268. https://doi.org/10.3390/v12030268

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Unidades organizacionais

Fascículo

Editora

MDPI

DOI

10.3390/v12030268

Coleções

EM - Artigos Científicos

Licença CC

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