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The effect of albumin and cholesterol on the biotribological behavior of hydrogels for contact lenses

2015-10Journal article Restricted access
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dc.contributor.authorSilva, D.
dc.contributor.authorFernandes, A. C.
dc.contributor.authorNunes, T. G.
dc.contributor.authorColaço, R.
dc.contributor.authorSerro, A. P.
dc.date.accessioned2017-06-07T10:04:44Z
dc.date.available2017-06-07T10:04:44Z
dc.date.issued2015-10
dc.description.abstractThe irritation/discomfort associated with the use of contact lenses (CLs) is often related to the eyelid-lens friction. Although the use of such devices is widespread, the information about the influence of the lacrimal fluid biomolecules on the tribological behavior of the CLs hydrogels is scarce. In this work, we investigated the effect of the presence of albumin and cholesterol in the lubricant medium, on the frictional response of two model hydrogels for CLs: a hydroxyethylmethacrylate based hydrogel, HEMA/PVP, and a silicone based one, TRIS/NVP/HEMA. Tribological experiments were done in a nanotribometer, in water and in the presence of solutions of those biomolecules. It was observed a significant increase of the friction coefficient (μ) for HEMA/PVP when the lubricant contains cholesterol, and for TRIS/NVP/HEMA when it contains albumin. Solid-state NMR and DSC analysis revealed that HEMA/PVP hydrated in cholesterol solution has a lower amount of free and loosely bound water than the hydrogel hydrated in water. Therefore, a smaller amount of water shall be released into the contact region during the friction tests with cholesterol solution, leading to a thinner film in the contact zone, and consequently to a higher μ. Concerning TRIS/NVP/HEMA, QCM-D studies showed that this hydrogel adsorbs less albumin than HEMA/PVP and that the formed film is more rigid, which can explain the increase of μ. The obtained results contribute to understand the influence of lacrimal fluid composition on the tribological behavior of CLs materials, being relevant for the selection and optimization of these devices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Biomater. 2015 Oct;26:184-94. doi: 10.1016/j.actbio.2015.08.011.pt_PT
dc.identifier.doi10.1016/j.actbio.2015.08.011pt_PT
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/10400.26/18485
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.actbio.2015.08.011pt_PT
dc.subjectHydrogelspt_PT
dc.subjectHEMApt_PT
dc.subjectSiliconept_PT
dc.subjectContact lensespt_PT
dc.subjectFriction coefficientpt_PT
dc.subjectCholesterolpt_PT
dc.subjectAlbuminpt_PT
dc.titleThe effect of albumin and cholesterol on the biotribological behavior of hydrogels for contact lensespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FQEQ-QIN%2F0189%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FQUI%2FUI0100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT
oaire.citation.endPage194pt_PT
oaire.citation.startPage184pt_PT
oaire.citation.titleActa Biomaterialiapt_PT
oaire.citation.volume26pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica de copyright do editorpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf86e3a56-3f5f-4ff4-9acf-45c08a78e4a9
relation.isProjectOfPublication09b9027b-a82d-4ab5-bd50-3b94fecdc5e9
relation.isProjectOfPublicationbf1cd7d5-a9c0-4159-91e5-1d72d8d3cf81
relation.isProjectOfPublication.latestForDiscoverybf1cd7d5-a9c0-4159-91e5-1d72d8d3cf81

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