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Controlled drug release from hydrogels for contact lenses: drug partitioning and diffusion

dc.contributor.authorPimenta, A.F.R.
dc.contributor.authorAscenso, J.
dc.contributor.authorFernandes, J.C.S.
dc.contributor.authorColaço, R.
dc.contributor.authorSerro, A.P.
dc.contributor.authorSaramago, B.
dc.date.accessioned2018-01-10T12:55:31Z
dc.date.available2018-01-10T12:55:31Z
dc.date.issued2016-12
dc.description.abstractOptimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorhexidine, levofloxacin and diclofenac. Equilibrium partition coefficients were determined at different ionic strength and pH, using water (pH 5.6) and PBS (pH 7.4). The measured partition coefficients were related with the polymer volume fraction in the hydrogel, through the introduction of an enhancement factor following the approach developed by the group of C. J. Radke (Kotsmar et al., 2012; Liu et al., 2013). This factor may be decomposed in the product of three other factors EHS, Eel and Ead which account for, respectively, hard-sphere size exclusion, electrostatic interactions, and specific solute adsorption. While EHS and Eel are close to 1, Ead > > 1 in all cases suggesting strong specific interactions between the drugs and the hydrogels. Adsorption was maximal for chlorhexidine on the silicone based hydrogel, in water, due to strong hydrogen bonding. The effective diffusion coefficients, De, were determined from the drug release profiles. Estimations of diffusion coefficients of the non-adsorbed solutes D = De × Ead allowed comparison with theories for solute diffusion in the absence of specific interaction with the polymeric membrane.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationA.F.R. Pimenta, J. Ascenso, J.C.S. Fernandes, R. Colaço, A.P. Serro, B. Saramago, Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion, International Journal of Pharmaceutics, Volume 515, Issues 1–2, 2016, Pages 467-475, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2016.10.047pt_PT
dc.identifier.doi10.1016/j.ijpharm.2016.10.047pt_PT
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/10400.26/20037
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSURFACE MODIFICATIONS TO CONTROL DRUG RELEASE FROM THERAPEUTIC OPHTHALMIC LENSES
dc.relation.publisherversionhttps://doi.org/10.1016/j.ijpharm.2016.10.047pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDrug releasept_PT
dc.subjectContact lenspt_PT
dc.subjectHydrogel membranept_PT
dc.subjectPartition coefficientpt_PT
dc.subjectDiffusion coefficientpt_PT
dc.titleControlled drug release from hydrogels for contact lenses: drug partitioning and diffusionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSURFACE MODIFICATIONS TO CONTROL DRUG RELEASE FROM THERAPEUTIC OPHTHALMIC LENSES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FQUI%2FUI0100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FQEQ-QIN%2F0189%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F52334%2F2013/PT
oaire.citation.endPage475pt_PT
oaire.citation.startPage467pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume515(1-2)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication09b9027b-a82d-4ab5-bd50-3b94fecdc5e9
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