Publicação
Causal association between periodontitis and Parkinson’s disease : a bidirectional Mendelian randomization study
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Botelho, João | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Mendes, José João | |
| dc.contributor.author | Mascarenhas, Paulo | |
| dc.date.accessioned | 2025-09-16T09:13:18Z | |
| dc.date.available | 2025-09-16T09:13:18Z | |
| dc.date.issued | 2021-05 | |
| dc.description.abstract | The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results. | eng |
| dc.identifier.citation | Botelho J, Machado V, Mendes JJ, Mascarenhas P. Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study. Genes. 2021; 12(5):772. https://doi.org/10.3390/genes12050772 | |
| dc.identifier.doi | 10.3390/genes12050772 | |
| dc.identifier.issn | 2073-4425 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58667 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/genes12050772 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Parkinson’s disease | |
| dc.subject | periodontitis | |
| dc.subject | periodontal disease | |
| dc.subject | Mendelian randomization | |
| dc.subject | bioinformatics | |
| dc.subject | oral health | |
| dc.title | Causal association between periodontitis and Parkinson’s disease : a bidirectional Mendelian randomization study | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 5 | |
| oaire.citation.startPage | 772 | |
| oaire.citation.title | Genes | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |