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Causal association between periodontitis and Parkinson’s disease : a bidirectional Mendelian randomization study
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Orientador(es)
Resumo(s)
The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results.
Descrição
Palavras-chave
Parkinson’s disease periodontitis periodontal disease Mendelian randomization bioinformatics oral health
Contexto Educativo
Citação
Botelho J, Machado V, Mendes JJ, Mascarenhas P. Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study. Genes. 2021; 12(5):772. https://doi.org/10.3390/genes12050772
Editora
MDPI