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Shaping the founders : naïve CD4 T cell heterogeneity in people with HIV-1 or HIV-2

2026-05Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBadura, Robert
dc.contributor.authorMartins, Nicole C.
dc.contributor.authorFarias, Guilherme B.
dc.contributor.authorTendeiro, Rita
dc.contributor.authorFoxall, Russell B.
dc.contributor.authorSantos, Diana F.
dc.contributor.authorGomes, André M. C.
dc.contributor.authorMarques, Rita T.
dc.contributor.authorMoleirinho, Beatriz
dc.contributor.authorGodinho-Santos, Ana C.
dc.contributor.authorValadas, Emília
dc.contributor.authorGomes, Perpétua
dc.contributor.authorAlmeida, Afonso R. M.
dc.contributor.authorSousa, Ana E.
dc.date.accessioned2026-07-06T10:14:23Z
dc.date.available2026-07-06T10:14:23Z
dc.date.issued2026-05
dc.description.abstractNaïve CD4 T cells harbour functional subsets that influence the quality of immune reconstitution and the persistent viral reservoirs in people with HIV (PWH) under antiretroviral therapy (ART). Here, we profiled the circulating naïve CD4 T cells from PWH under effective ART with distinct past histories of viral burden, namely starting treatment early in acute or late in chronic stage HIV-1 infection, and people with HIV-2 (PWH2), who feature low to undetectable viremia before ART and slow disease progression. Spectral flow cytometry enabled us to capture the heterogeneity of this overlooked T cell compartment. Early-treated PWH1 maintained a naïve CD4 T cell profile comparable to that of age-matched seronegative individuals. Late-treated PWH1 and PWH2 showed distinct imbalances in conventional and regulatory subpopulations, yet both exhibited a relative expansion of CD31-expressing naïve cells, consistent with an IL-7-mediated homeostatic response. The ability of purified naïve CD4 T cells to respond to IL-7 was evaluated in additional cohorts of untreated PWH, revealing reduced proliferation and increased p21 transcription in PWH1 elite controllers. Additionally, a significant decline in proviral DNA was found in PWH2, suggesting an impact of IL-7 on HIV-2-infected naïve CD4 T cells that was not observed in the case of HIV-1 infection. Unravelling the homeostatic pathways and functional implications of naïve CD4 T cell heterogeneity will help clarify viral reservoir dynamics and inflammation in PWH and define strategies to prevent immune senescence.eng
dc.identifier.citationBadura R, Martins NC, Farias GB, Tendeiro R, Foxall RB, Santos DF, Gomes AMC, Marques RT, Moleirinho B, Godinho-Santos AC, Valadas E, Gomes P, Almeida ARM and Sousa AE (2026) Shaping the founders: naïve CD4 T cell heterogeneity in people with HIV-1 or HIV-2. Front. Immunol. 17:1810186. doi: 10.3389/fimmu.2026.1810186
dc.identifier.doi10.3389/fimmu.2026.1810186
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.26/63731
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relation.hasversionhttps://doi.org/10.3389/fimmu.2026.1810186
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectacute HIV-1 infection
dc.subjectCD31
dc.subjectelite controllers
dc.subjectHIV/AIDS
dc.subjectHIV-2
dc.subjectIL-7
dc.subjectmemory stem-cells
dc.subjectnaïve CD4 T cells
dc.titleShaping the founders : naïve CD4 T cell heterogeneity in people with HIV-1 or HIV-2eng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage1810186
oaire.citation.titleFrontiers in Immunology
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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