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Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in black merino sheep temporomandibular joint: TEMPOJIMS – Phase 1- histologic, imaging and body weight results

2018-04Journal article Restricted access
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dc.contributor.authorÂngelo, David Faustino
dc.contributor.authorMorouço, Pedro
dc.contributor.authorGil, Florencio Monje
dc.contributor.authorMónico, Lisete
dc.contributor.authorGonzález-Gárcia, Raúl
dc.contributor.authorSousa, Rita
dc.contributor.authorNeto, Lia
dc.contributor.authorCaldeira, Inês
dc.contributor.authorSmith, Margaret
dc.contributor.authorSmith, Susan
dc.contributor.authorSanz, David
dc.contributor.authorSantos, Fábio Abade dos
dc.contributor.authorPinho, Mário
dc.contributor.authorCarrapiço, Belmira
dc.contributor.authorCavaco, Sandra
dc.contributor.authorMoura, Carla
dc.contributor.authorAlves, Nuno
dc.contributor.authorSalvado, Francisco
dc.contributor.authorLittle, Christopher
dc.date.accessioned2020-07-31T15:38:07Z
dc.date.available2020-07-31T15:38:07Z
dc.date.issued2018-04
dc.description.abstractIntroduction: The role of temporomandibular joint (TMJ) surgery is not well defined due to a lack of quality randomized controlled clinical trials, comparing different TMJ surgical treatments with medical and placebo interventions. The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS - phase 1, aims to evaluate histopathologic and imaging changes of bilateral discectomy and discopexy in Black Merino sheep TMJ, using a high-quality trial following the ARRIVE guidelines. Material and methods: This randomized, blinded and controlled preclinical trial was conducted in 9 Black Merino sheep to investigate histopathologic (primary outcome), imaging and body weight (secondary outcomes) changes after bilateral discectomy, discopexy and sham surgery. Results: Significant changes were noticed in discectomy group, both in imaging and histopathologic analyses. Body weight changes were most pronounced in the discectomy group in the first 4 months after surgery with recovery to baseline weight 6 months after surgery. Discopexy induced nonsignificant changes in histopathologic, imaging and body weight analyses. Conclusions: This study reinforces the importance of developing an effective interposal material to substitute the TMJ disc and the need to explore the molecular mechanisms that underlie TMJ cartilage degeneration. The study design proposed in TEMPOJIMS represents an important progress towards future rigorous TMJ investigations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationÂngelo DF, Morouço P, Monje Gil F, et al. Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS - Phase 1- histologic, imaging and body weight results. J Craniomaxillofac Surg. 2018;46(4):688-696. doi:10.1016/j.jcms.2018.01.006pt_PT
dc.identifier.doi10.1016/j.jcms.2018.01.006pt_PT
dc.identifier.issn1010-5182
dc.identifier.urihttp://hdl.handle.net/10400.26/33034
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.jcms.2018.01.006pt_PT
dc.subjectPreclinical studypt_PT
dc.subjectTMJ discpt_PT
dc.subjectTMJ discectomypt_PT
dc.subjectTMJ discopexypt_PT
dc.subjectTMJ histologypt_PT
dc.subjectTMJ imagingpt_PT
dc.titlePreclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in black merino sheep temporomandibular joint: TEMPOJIMS – Phase 1- histologic, imaging and body weight resultspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage696pt_PT
oaire.citation.startPage688pt_PT
oaire.citation.titleJournal of Cranio-Maxillofacial Surgerypt_PT
oaire.citation.volume46(4)pt_PT
rcaap.embargofctPolítica de copyright do editorpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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