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Profile of cognitive impairment in late-stage Parkinson's disease

2022-04Journal article Open access
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dc.contributor.authorSousa, Catarina Severiano e
dc.contributor.authorFabbri, Margherita
dc.contributor.authorGodinho, Catarina
dc.contributor.authorSimões, Rita Moiron
dc.contributor.authorChendo, Inês
dc.contributor.authorCoelho, Miguel
dc.contributor.authorMartins, Isabel Pavão
dc.contributor.authorFerreira, Joaquim J.
dc.date.accessioned2022-05-10T15:00:27Z
dc.date.available2022-05-10T15:00:27Z
dc.date.issued2022-04
dc.description.abstractIntroduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management.pt_PT
dc.description.abstractMethods: In this cross-sectional study, we characterized the cognitive profile of LSPD patients using the comprehensive assessment methodology proposed by the International Parkinson and Movement Disorders Society Task Force. The association of clinical and demographic variables with dementia diagnosis was also investigated using binary logistic regression analysis.pt_PT
dc.description.abstractResults: Eighty-four LSPD patients were included (age 75.4 ± 6.9; disease duration 16.9 ± 7.5). Fifty-four (64.3%) were classified as demented and presented a global impairment cognitive profile. In the nondemented group (N = 30), 25 (83.3%) LSPD patients met the diagnostic criteria for mild cognitive impairment, mostly with multiple domain impairment (96.0%) and a heterogeneous profile. Memory was the most frequent and severely impaired cognitive domain in both groups. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities were significantly associated with dementia diagnosis (p < .05).pt_PT
dc.description.abstractConclusions: Cognitive impairment in multiple domains was common in LSPD patients. The most frequent and prominent deficits were in the memory domain, with a strong interference from attention impairment. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities proved to be important determinants for dementia diagnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSeveriano e Sousa, C., Fabbri, M., Godinho, C., Moiron Simões, R., Chendo, I., Coelho, M., Pavão Martins, I., & Ferreira, J. J. (2022). Profile of cognitive impairment in late-stage Parkinson's disease. Brain and Behavior, 12, e2537. https://doi.org/10.1002/brb3.2537pt_PT
dc.identifier.doi10.1002/brb3.2537pt_PT
dc.identifier.issn2162-3279
dc.identifier.urihttp://hdl.handle.net/10400.26/40487
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationCognitive Disorders in Late-Stage Parkinson´s Disease
dc.relation.publisherversionhttps://doi.org/10.1002/brb3.2537pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCognitive impairmentpt_PT
dc.subjectLate-stagept_PT
dc.subjectParkinson’s diseasept_PT
dc.titleProfile of cognitive impairment in late-stage Parkinson's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCognitive Disorders in Late-Stage Parkinson´s Disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F139853%2F2018/PT
oaire.citation.startPagee2537pt_PT
oaire.citation.titleBrain and Behaviorpt_PT
oaire.citation.volume12(4)pt_PT
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationbaff15eb-b8b1-4719-b929-1ae68dc51c6b
relation.isProjectOfPublication.latestForDiscoverybaff15eb-b8b1-4719-b929-1ae68dc51c6b

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