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Alterações salivares na diabetes
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Abstract(s)
A Diabetes Mellitus (DM) é uma doença crónica de origem endócrina que afeta milhões de pessoas em todo o mundo, sendo o resultado de uma deficiência na secreção de insulina e/ou na sua ação. O aumento da prevalência da DM ao longo dos anos, assim como das suas morbilidades, tornou-se um importante problema de saúde pública a nível mundial.
A saliva é um fluido de extrema importância para a manutenção da homeostasia do corpo humano, e alterações quantitativas e/ou qualitativas podem levar a severas complicações na saúde do indivíduo. A saliva para além das funções protetoras e digestivas, ainda tem um papel na própria fonação do indivíduo. O diagnóstico salivar oferece uma abordagem fácil, barata, segura e não-invasiva para a deteção precoce de doenças orais, assim como sistémicas.
A principal característica da DM é a hiperglicemia (elevados níveis de glicose no sangue), a qual está associada a complicações macro e microvasculares, com consequente compromisso da função das glândulas salivares, levando à redução da excreção de saliva e a alterações na sua composição. Estas alterações detetáveis na saliva tornam-na numa fonte de biomarcadores na deteção de inúmeras doenças.
Diabetes Mellitus (DM) is a chronic endocrine disease that affects millions of people around the world and is the result of a deficiency in insulin secretion and/or its action. The increased prevalence of DM over the years, as well as its morbidities, has become an important public worldwide health problem. Saliva is a fluid of extreme importance for the maintenance of human body homeostasis, and quantitative and/or qualitative changes can lead to severe complications in the individual’s health. Saliva, besides the protective and digestive functions, still has a role in the individual’s own phonation. The salivary diagnosis offers an easy, non-expensive, safe and non-invasive approach to the early detection of oral as well as systemic diseases. The main characteristic of DM is hyperglycemia (high blood glucose levels), which is associated with macro and microvascular complications, with a consequent commitment of salivary gland function, leading to reduced excretion of saliva and changes in its composition. These detectable changes in saliva make it a source of biomarkers in detecting numerous diseases.
Diabetes Mellitus (DM) is a chronic endocrine disease that affects millions of people around the world and is the result of a deficiency in insulin secretion and/or its action. The increased prevalence of DM over the years, as well as its morbidities, has become an important public worldwide health problem. Saliva is a fluid of extreme importance for the maintenance of human body homeostasis, and quantitative and/or qualitative changes can lead to severe complications in the individual’s health. Saliva, besides the protective and digestive functions, still has a role in the individual’s own phonation. The salivary diagnosis offers an easy, non-expensive, safe and non-invasive approach to the early detection of oral as well as systemic diseases. The main characteristic of DM is hyperglycemia (high blood glucose levels), which is associated with macro and microvascular complications, with a consequent commitment of salivary gland function, leading to reduced excretion of saliva and changes in its composition. These detectable changes in saliva make it a source of biomarkers in detecting numerous diseases.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Diabetes mellitus Saliva Alterações salivares