Publicação
Botulinum toxin-A for the treatment of myogenous temporomandibular disorders : an umbrella review of systematic reviews
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Canales, Giancarlo De la Torre | |
| dc.contributor.author | Câmara-Souza, Mariana Barbosa | |
| dc.contributor.author | Ernberg, Malin | |
| dc.contributor.author | Al-Moraissi, Essam Ahmed | |
| dc.contributor.author | Grigoriadis, Anastasios | |
| dc.contributor.author | Poluha, Rodrigo Lorenzi | |
| dc.contributor.author | Christidis, Maria | |
| dc.contributor.author | Jasim, Hajer | |
| dc.contributor.author | Lövgren, Anna | |
| dc.contributor.author | Christidis, Nikolaos | |
| dc.date.accessioned | 2026-03-20T15:01:37Z | |
| dc.date.available | 2026-03-20T15:01:37Z | |
| dc.date.issued | 2024-06 | |
| dc.description.abstract | Objective: Temporomandibular disorders (TMDs) encompass several conditions that cause pain and impair function of the masticatory muscles (M-TMDs) and temporomandibular joints. There is a large interest among clinicians and researchers in the use of botulinum toxin-A (BoNT-A) as a treatment for M-TMD. However, due to the lack of consistent evidence regarding the efficacy as well as adverse events of BoNT-A, clinical decision making is challenging. Therefore, this umbrella review aimed to systematically assess systematic reviews (SRs) evaluating BoNT-A treatment effects on pain intensity, mandibular movements, and adverse events in patients with M-TMDs. Method: An electronic search was undertaken in the databases MEDLINE, EMBASE, CINAHL, Cochrane Central Registry of Controlled Trials (CENTRAL), Web of Science, Epistemonikos, ClinicalTrials.gov, and ICTRP to identify SRs investigating BoNT-A effects on M-TMDs, published from the inception of each database until 6 December 2023. The quality of evidence was rated according to the critical appraisal checklist developed by the umbrella review methodology working group. Only high-quality SRs were included. Results: In total, 18 SRs were included. BoNT-A was shown to be more effective than placebo to reduce pain intensity, but not compared to standard treatments. Additionally, BoNT-A was not superior to placebo or standard treatments regarding improvement of mandibular movements. BoNT-A was considered to have a higher risk for adverse events on muscle and bony tissue compared with other treatments. Conclusion: The synthesis in this umbrella review provides the highest level of evidence present. Taken together, there are indications of effectiveness of BoNT-A for treatment of M-TMDs, supported by moderate evidence. However, considering the risk of causing serious adverse events, treatment with BoNT-A is recommended to be the last treatment alternative. | eng |
| dc.identifier.citation | De la Torre Canales, G., Câmara-Souza, M.B., Ernberg, M. et al. Botulinum Toxin-A for the Treatment of Myogenous Temporomandibular Disorders: An Umbrella Review of Systematic Reviews. Drugs 84, 779–809 (2024). https://doi.org/10.1007/s40265-024-02048-x | |
| dc.identifier.doi | 10.1007/s40265-024-02048-x | |
| dc.identifier.issn | 1179-1950 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62329 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Springer Nature | |
| dc.relation.hasversion | https://doi.org/10.1007/s40265-024-02048-x | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Temporomandibular disorders | |
| dc.subject | botulinum toxin-A | |
| dc.subject | BoNT-A | |
| dc.subject | M-TMD | |
| dc.title | Botulinum toxin-A for the treatment of myogenous temporomandibular disorders : an umbrella review of systematic reviews | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 809 | |
| oaire.citation.startPage | 779 | |
| oaire.citation.title | Drugs | |
| oaire.citation.volume | 84 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |