Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis

Ferret-Sena, Véronique; Capela, Carlos; Sena, Armando

http://hdl.handle.net/10400.26/30165

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Authors

Ferret-Sena, Véronique

Capela, Carlos

Sena, Armando

Abstract(s)

"Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease."

Keywords

Immune system Metabolism Multiple sclerosis Neurodegeneration Neuroinflammation Peroxisome proliferator-activated receptors

URI

http://hdl.handle.net/10400.26/30165

Citation

Ferret-Sena, V.; Capela, C.; Sena, A. Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis. Int. J. Mol. Sci. 2018, 19, 1639.