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As metaloproteinases no movimento dentário ortodôntico : uma revisão narrativa
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Abstract(s)
As metaloproteinases de matriz (MMP) são enzimas cruciais no processo de movimentação ortodôntica porque desempenham um papel importante na remodelação do tecido periodontal e permitem a reabsorção e formação de tecido ósseo durante o tratamento ortodôntico. Estas enzimas pertencem à família das protéases e estão envolvidas na degradação e remodelação da matriz extracelular (MEC) que envolve os dentes e tecidos circundantes.
As forças aplicadas aos dentes durante a ortodontia causam uma resposta inflamatória local nos tecidos periodontais. Isso libera citocinas e fatores de crescimento que estimulam a atividade das metaloproteinases. Vários tipos de metaloproteinases estão envolvidos no processo de movimentação ortodôntica, incluindo colagenases, gelatinases e estromelisinas.
Devido à importância da participação das MMP durante o movimento dentário ortodôntico essa revisão narrativa descreve o comportamento dessas enzimas, além de apresentar uma visão geral da sua função, regulação, ativação e inibição. Essa tese teve como objetivo rever a evidência atual sobre o envolvimento das metalopeptidases no movimento dentário ortodôntico.
Matrix metalloproteinases (MMPs) are crucial enzymes in the orthodontic movement process, as they play an important role in the remodelling of periodontal tissue and enable the resorption and formation of bone tissue during orthodontic treatment. These enzymes belong to the protease family and are involved in the degradation and remodelling of the extracellular matrix (ECM) that surrounds the teeth and adjacent tissues. The forces applied to the teeth during orthodontics cause a local inflammatory response in the periodontal tissues. This releases cytokines and growth factors that stimulate the activity of metalloproteinases. Several types of metalloproteinases are involved in the orthodontic movement process, including collagenase, gelatinase and stromelysin. Due to the importance of the participation of MMP during orthodontic tooth movement, this narrative review describes the behaviour of these enzymes, as well as providing an overview of their function, regulation, activation and inhibition. This thesis aimed to review the current evidence on the involvement of metallopeptidases in orthodontic tooth movement.
Matrix metalloproteinases (MMPs) are crucial enzymes in the orthodontic movement process, as they play an important role in the remodelling of periodontal tissue and enable the resorption and formation of bone tissue during orthodontic treatment. These enzymes belong to the protease family and are involved in the degradation and remodelling of the extracellular matrix (ECM) that surrounds the teeth and adjacent tissues. The forces applied to the teeth during orthodontics cause a local inflammatory response in the periodontal tissues. This releases cytokines and growth factors that stimulate the activity of metalloproteinases. Several types of metalloproteinases are involved in the orthodontic movement process, including collagenase, gelatinase and stromelysin. Due to the importance of the participation of MMP during orthodontic tooth movement, this narrative review describes the behaviour of these enzymes, as well as providing an overview of their function, regulation, activation and inhibition. This thesis aimed to review the current evidence on the involvement of metallopeptidases in orthodontic tooth movement.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Metaloproteinases Fluido crevicular gengival Movimento dentário ortodôntico