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Exposure assessment of the European adult population to deoxynivalenol – results from the HBM4EU Aligned Studies

2024-12Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorNamorado, Sónia
dc.contributor.authorMartins, Carla
dc.contributor.authorOgura, Joana
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorVasco, Elsa
dc.contributor.authorAppenzeller, Brice
dc.contributor.authorHalldorsson, Thorhallur I.
dc.contributor.authorJanasik, Beata
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorNieuwenhuyse, An Van
dc.contributor.authorÓlafsdóttir, Kristin
dc.contributor.authorRambaud, Loïc
dc.contributor.authorRiou, Margaux
dc.contributor.authorSilva, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorWeber, Till
dc.contributor.authorEsteban-López, Marta
dc.contributor.authorCastaño, Argelia
dc.contributor.authorGilles, Liese
dc.contributor.authorMartin, Laura Rodríguez
dc.contributor.authorGovarts, Eva
dc.contributor.authorSchoeters, Greet
dc.contributor.authorViegas, Susana
dc.contributor.authorSilva, Maria João
dc.contributor.authorAlvito, Paula
dc.date.accessioned2026-04-01T08:09:23Z
dc.date.available2026-04-01T08:09:23Z
dc.date.issued2024-12
dc.description.abstractMycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the internal exposure of the adult European population and identify the most relevant determinants of exposure. tDON concentrations’ P50 and P95 were in the range of 0.41–10.16 µg/L (0.39–9.05 µg/g crt) and 3.25–46.58 µg/L (2.12–33.50 µg/g crt) respectively. Higher tDON levels were observed for (i) male participants from France and Germany, (ii) samples collected in spring and summer, (iii) participants with a lower educational level, (iv) participants living in rural areas, (v) individuals without a job in France and Luxembourg, while in Portugal higher exposure was observed in working individuals, (vi) individuals with higher consumption of cereals and bread. The proportion of individuals with exposure levels exceeding the HBM-GV of 23 µg/L was 12.3 %, ranging from 0.8 % to 20.7 % in the individual countries. This study on mycotoxins exposure has used post harmonized questionnaire data and validated analytical methodologies for analysis and covered countries representing the four geographical regions of Europe, having produced much needed knowledge on the exposure of the European adult population to deoxynivalenol.eng
dc.identifier.citationNamorado, S., Martins, C., Ogura, J., Assunção, R., Vasco, E., Appenzeller, B., I Halldorsson, T., Janasik, B., Kolossa-Gehring, M., Van Nieuwenhuyse, A., Ólafsdóttir, K., Rambaud, L., Riou, M., Silva, S., Wasowicz, W., Weber, T., Esteban-López, M., Castaño, A., Gilles, L., Rodríguez Martin, L., … Alvito, P. (2024). Exposure assessment of the European adult population to deoxynivalenol - Results from the HBM4EU Aligned Studies. Food research international (Ottawa, Ont.), 198, 115281. https://doi.org/10.1016/j.foodres.2024.115281
dc.identifier.doi10.1016/j.foodres.2024.115281
dc.identifier.issn1873-7145
dc.identifier.urihttp://hdl.handle.net/10400.26/62555
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://doi.org/10.1016/j.foodres.2024.115281
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMycotoxins
dc.subjectDeoxynivalenol
dc.subjectHBM4EU
dc.subjectHuman biomonitoring
dc.subjectChemical exposure
dc.subjectRisk assessment
dc.titleExposure assessment of the European adult population to deoxynivalenol – results from the HBM4EU Aligned Studieseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage115281
oaire.citation.titleFood Research International
oaire.citation.volume198
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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