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Publication
New Developments in Celiac Disease Treatment
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Abstract(s)
Celiac disease (CD) is a common autoimmune disease affecting around 1% of the population.
It consists of an immune-mediated enteropathy, triggered by gluten exposure in susceptible patients.
All patients with CD, irrespective of the presence of symptoms, must endure a lifelong gluten-free
diet (GFD). This is not an easy task due to a lack of awareness of the gluten content in foods and
the extensive incorporation of gluten in processed foods. Furthermore, a GFD imposes a sense of
limitation and might be associated with decreased quality of life in CD patients. This results in gluten
contamination in the diet of four out of five celiac patients adhering to a GFD. Furthermore, one in
three adult patients will report persistent symptoms and two in three will not achieve full histological
recovery when on a GFD. In recent years, there has been extensive research conducted in the quest to
find the holy grail of pharmacological treatment for CD. This review will present a concise description
of the current rationale and main clinical trials related to CD drug therapy.
Description
Keywords
celiac disease gluten-free diet pharmacological treatments