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The Role Of Neuroinflammation In Idiopathic Epilepsy In Dogs: A Systematic Review
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Este estudo explora o impacto da neuroinflamação na epilepsia idiopática em cães através de uma revisão sistemática abrangente que engloba estudos em animais de laboratório, cães e seres humanos. Os objetivos incluem a investigação da correlação entre a neuroinflamação e a epilepsia idiopática, a compreensão das causas da inflamação do sistema nervoso central em cães e a avaliação da eficácia das modalidades de tratamento atuais.
As descobertas revelam que a neuroinflamação é um fator comum tanto em cães como em humanos, potencialmente levando a epilepsia idiopática. Os fatores que conduzem à neuroinflamação incluem a proliferação glial, o aumento da produção de mediadores inflamatórios, a rutura da barreira hematoencefálica e o aumento das vias de sinalização no sistema nervoso central. Vários mediadores inflamatórios, incluindo citocinas, quimiocinas e componentes do inflamassoma, estão elevados em cães com epilepsia idiopática.
O estudo conclui que os tratamentos mais eficazes para a epilepsia idiopática canina dependem frequentemente de uma análise caso a caso, envolvendo normalmente a administração de fenobarbital, brometo de potássio ou imepitoína. Embora alguma evidência sugira que os fármacos anti-inflamatórios podem ajudar a aliviar os sintomas da epilepsia ao atuarem sobre a neuroinflamação subjacente, é necessária mais investigação para estabelecer a sua eficácia.
As limitações deste estudo incluem fontes de dados variáveis, potenciais enviesamentos e desafios inerentes à investigação de condições raras. É imperativo efetuar mais investigação, tanto em medicina humana como veterinária, para obter informações mais aprofundadas sobre estes aspectos.
This research explores the impact of neuroinflammation on idiopathic epilepsy in dogs through a comprehensive systematic review encompassing studies on laboratory animals, dogs, and humans. Objectives include investigating the correlation between neuroinflammation and idiopathic epilepsy, understanding the causes of central nervous system inflammation in dogs, and evaluating the effectiveness of current treatment modalities. The findings reveal neuroinflammation as a common factor in both dogs and humans, potentially leading to idiopathic epilepsy. Factors driving neuroinflammation encompass glial proliferation, increased production of inflammatory mediators, disruption of the blood-brain barrier, and heightened signaling pathways within the central nervous system. Various inflammatory mediators, including cytokines, chemokines, and inflammasome components, are elevated in dogs with idiopathic epilepsy. The study concludes that the most effective treatments for canine idiopathic epilepsy often depend on a case-by-case basis, typically involving the administration of phenobarbital, potassium bromide, or imepitoin. While some evidence suggests that anti-inflammatory drugs may help alleviate epilepsy symptoms by addressing the underlying neuroinflammation, further research is needed to establish their efficacy. Limitations of this study include variable data sources, potential biases, and inherent challenges in investigating rare conditions. Further research is imperative in both human and veterinary medicine to gain deeper insights into these aspects.
This research explores the impact of neuroinflammation on idiopathic epilepsy in dogs through a comprehensive systematic review encompassing studies on laboratory animals, dogs, and humans. Objectives include investigating the correlation between neuroinflammation and idiopathic epilepsy, understanding the causes of central nervous system inflammation in dogs, and evaluating the effectiveness of current treatment modalities. The findings reveal neuroinflammation as a common factor in both dogs and humans, potentially leading to idiopathic epilepsy. Factors driving neuroinflammation encompass glial proliferation, increased production of inflammatory mediators, disruption of the blood-brain barrier, and heightened signaling pathways within the central nervous system. Various inflammatory mediators, including cytokines, chemokines, and inflammasome components, are elevated in dogs with idiopathic epilepsy. The study concludes that the most effective treatments for canine idiopathic epilepsy often depend on a case-by-case basis, typically involving the administration of phenobarbital, potassium bromide, or imepitoin. While some evidence suggests that anti-inflammatory drugs may help alleviate epilepsy symptoms by addressing the underlying neuroinflammation, further research is needed to establish their efficacy. Limitations of this study include variable data sources, potential biases, and inherent challenges in investigating rare conditions. Further research is imperative in both human and veterinary medicine to gain deeper insights into these aspects.
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Keywords
Etiologia Sistema Nervoso Central Epilepsia Idiopática Mediadores Neuroinflamação Convulsão Tratamento Aetiology Central Nervous System Idiopathic Epilepsy Mediators Neuroinflammation Seizure Treatment