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Publication
Estudo das moléculas bioativas da soja e seu impacto na prevenção e no suporte ao tratamento do cancro da mama
| Name: | Description: | Size: | Format: | |
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| 1.6 MB | Adobe PDF |
Advisor(s)
Abstract(s)
O cancro da mama continua a ser um dos principais desafios globais de saúde pública, representando uma causa importante de morbilidade e mortalidade entre as mulheres. As limitações dos tratamentos convencionais têm suscitado um interesse crescente em estratégias complementares, nas quais a nutrição desempenha um papel cada vez mais relevante. A soja, rica em moléculas bioativas como as isoflavonas, surgiu como um candidato promissor devido às suas propriedades estrogénicas seletivas, efeitos
antioxidantes e capacidade de regular a proliferação celular.
Dados experimentais, epidemiológicos e clínicos sugerem que estes compostos podem contribuir para a prevenção e para o apoio terapêutico no cancro da mama.
Contudo, persistem controvérsias particularmente no que respeita à sua segurança em doentes com tumores hormono-dependentes e às suas potenciais interações com as terapias convencionais.
A evidência atual destaca simultaneamente o potencial promissor das isoflavonas da soja e a necessidade de abordagens clínicas mais rigorosas e personalizadas, de modo a definir melhor o seu papel na gestão integrativa do cancro da mama
Breast cancer remains one of the leading global public health challenges, representing a major cause of morbidity and mortality among women. The limitation of conventional treatments have prompted going interest in complementary strategies, with nutrition playing an increasingly important role. Soy rich in bioactive molecule such as isoflavones, has emerged as a promising candidate due to its selective estrogenic properties, antioxidant effects, and regulation of cell proliferation. Experimental, epidemiological, and clinical data suggest that these compounds may contribute to the prevention and supportive management of breast cancer. However, controversies persist, particularly regarding their safety in patients with hormonedependant tumors and their potential interactions with conventional therapies. Current evidence highlights both the promising potential of soy isoflavones and the need for more rigorous and personalized clinical approaches to better define their role in the integrative management of breast cancer.
Breast cancer remains one of the leading global public health challenges, representing a major cause of morbidity and mortality among women. The limitation of conventional treatments have prompted going interest in complementary strategies, with nutrition playing an increasingly important role. Soy rich in bioactive molecule such as isoflavones, has emerged as a promising candidate due to its selective estrogenic properties, antioxidant effects, and regulation of cell proliferation. Experimental, epidemiological, and clinical data suggest that these compounds may contribute to the prevention and supportive management of breast cancer. However, controversies persist, particularly regarding their safety in patients with hormonedependant tumors and their potential interactions with conventional therapies. Current evidence highlights both the promising potential of soy isoflavones and the need for more rigorous and personalized clinical approaches to better define their role in the integrative management of breast cancer.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Soja Cancro da mama Isoflavonas Fitoestrogénios