Publication
Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test
| dc.contributor.author | Fabbri, Margherita | |
| dc.contributor.author | Coelho, Miguel | |
| dc.contributor.author | Guedes, Leonor Correia | |
| dc.contributor.author | Chendo, Inês | |
| dc.contributor.author | Sousa, Catarina | |
| dc.contributor.author | Rosa, Mario M. | |
| dc.contributor.author | Abreu, Daisy | |
| dc.contributor.author | Costa, Nilza | |
| dc.contributor.author | Godinho, Catarina | |
| dc.contributor.author | Antonini, Angelo | |
| dc.contributor.author | Ferreira, Joaquim J. | |
| dc.date.accessioned | 2019-10-11T11:19:01Z | |
| dc.date.available | 2019-10-11T11:19:01Z | |
| dc.date.issued | 2017-06 | |
| dc.description | Article under a CC-BY-NC-ND license - https://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.description.abstract | "BACKGROUND: Non-motor symptoms (NMS) are extremely common among late-stage Parkinson's disease (LSPD) patients. Levodopa (L-dopa) responsiveness seems to decrease with disease progression but its effect on NMS in LSPD still needs to be investigated. OBJECTIVE: To assess the response of blood pressure (BP), pain, fatigue and anxiety to L-dopa in LSPD patients. METHODS: 20 LSPD patients, defined as Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 (MED ON) and 22 PD patients treated with subthalamic deep brain stimulation (advanced PD group) underwent an L-dopa challenge. BP and orthostatic hypotension (OH) assessment, a visual analogue scale (VAS) for pain and fatigue and the Strait Trait Anxiety (STAI) were evaluated before and after the L-dopa challenge. RESULTS: Systolic BP dropped significantly after L-dopa intake (p < 0.05) in LSPD patients, while there was no change in pain, fatigue or anxiety. L-dopa significantly improved (p < 0.05) pain and anxiety in the advanced PD group, whereas it had no effect on BP or fatigue. L-dopa-related adverse effects (AEs), namely OH and sleepiness, were more common among LSPD patients. 40% and 65% of LSPD patients were not able to fill out the VAS and the STAI, respectively, while measurement of orthostatic BP was not possible in four LSPD patients. CONCLUSIONS: This exploratory study concludes that some non-motor variables in LSPD do not benefit from the acute action of L-dopa while it can still induce disabling AEs. There is a need for assessment tools of NMS adapted to these disabled LSPD patients." | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Parkinsonism Relat Disord. 2017 Jun;39:37-43. doi: 10.1016/j.parkreldis.2017.02.007 | pt_PT |
| dc.identifier.doi | 10.1016/j.parkrelis.2017.02.007 | pt_PT |
| dc.identifier.issn | 1353-8020 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/29941 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://doi.org/10.1016/j.parkreldis.2017.02.007 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Parkinson's disease | pt_PT |
| dc.subject | Late-stage | pt_PT |
| dc.subject | Levodopa | pt_PT |
| dc.subject | Non-motor symptoms | pt_PT |
| dc.title | Response of non-motor symptoms to levodopa in late-stage Parkinson's disease: results of a levodopa challenge test | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 43 | pt_PT |
| oaire.citation.startPage | 37 | pt_PT |
| oaire.citation.title | Parkinsonism and Related Disorders | pt_PT |
| oaire.citation.volume | 39 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |