Loading...
Publication
Perspetivas de diagnóstico e tratamento em tumores de mama de cadelas
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 737.31 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Os tumores de mama são as neoplasias reprodutivas mais frequentes em cadelas inteiras. A
exposição hormonal ao estrogénio e progesterona contribui para um aumento do risco de tumor de
mama, sendo que a ovariohisterectomia realizada preventivamente reduz o efeito hormonal na glândula
mamária.
O uso de técnicas de imagem como a radiografia torácica e a tomografia axial é fundamental
para o estadiamento, contribuindo assim para a escolha do tipo de cirurgia.
As terapias como a quimioterapia, a radioterapia, a hormonoterapia, os anti-inflamatórios não
esteroides e os inibidores da tirosina quinase podem ser utilizados no pós-cirúrgico, como tratamento
adjuvante, ou como tratamento único em casos específicos, principalmente em carcinomas
inflamatórios ou em tumores com metástases à distância.
Os biomarcadores tumorais são cada vez mais fundamentais no diagnóstico, na decisão
terapêutica e na determinação do prognóstico. Nos tumores mamários caninos os mais utilizados são
os biomarcadores de proliferação tumoral.
A melhoria dos métodos de diagnóstico como o recurso a software para a avaliação das
imagens histopatológicas e a pesquisa de novos biomarcadores têm sido foco de estudo em tumores
de mama nas cadelas.
Breast tumors are the most frequent reproductive neoplasms in intact female dogs. Hormonal exposure to estrogen and progesterone contributes to an increased risk of breast tumor, and ovariohysterectomy performed preventively reduces the hormonal effect on the mammary gland. The use of imaging techniques such as thoracic radiography and axial tomography is essential for staging, thus providing confidence in choosing the type of surgery. Therapies such as chemotherapy, radiotherapy, hormone therapy, non-steroidal anti-inflammatory drugs and tyrosine kinase inhibitors can be used after surgery, as an adjuvant treatment, or as a single treatment in specific cases, mainly in inflammatory carcinomas or in tumors with distant metastases. Tumor biomarkers are increasingly essential in diagnosis, therapeutic decision and prognosis determination. In canine mammary tumors, the most used are proliferation tumor biomarkers. The improvement of diagnostic methods, such as the use of software for the evaluation of histopathological images and the search for new biomarkers, have been the focus of studies on breast disorders in female dogs.
Breast tumors are the most frequent reproductive neoplasms in intact female dogs. Hormonal exposure to estrogen and progesterone contributes to an increased risk of breast tumor, and ovariohysterectomy performed preventively reduces the hormonal effect on the mammary gland. The use of imaging techniques such as thoracic radiography and axial tomography is essential for staging, thus providing confidence in choosing the type of surgery. Therapies such as chemotherapy, radiotherapy, hormone therapy, non-steroidal anti-inflammatory drugs and tyrosine kinase inhibitors can be used after surgery, as an adjuvant treatment, or as a single treatment in specific cases, mainly in inflammatory carcinomas or in tumors with distant metastases. Tumor biomarkers are increasingly essential in diagnosis, therapeutic decision and prognosis determination. In canine mammary tumors, the most used are proliferation tumor biomarkers. The improvement of diagnostic methods, such as the use of software for the evaluation of histopathological images and the search for new biomarkers, have been the focus of studies on breast disorders in female dogs.
Description
Keywords
Diagnóstico Estadiamento Prognóstico Novas perspetivas Tratamento Tumor de mama cadela Canine mammary tumor Diagnosis Prognosis New perspectives Staging Treatment