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Manifestações orais do lúpus eritematoso sistémico
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Abstract(s)
O lúpus eritematoso sistémico (LES) é uma doença autoimune crónica e multissistêmica (Leite et al., 2015), que afeta entre 12 e 50 por 100 000 pessoas no mundo (Saccucci et al., 2018). Esta doença, leva a lesão tecidular em múltiplos órgãos, incluindo rins, pulmões, articulações, coração e cérebro (AlOmair et al., 2023; Graves et al., 2018). A etiologia e patogénese do LES não são bem conhecida, dificultando o diagnóstico e a escolha do tratamento adequado (García-Ríos et al., 2022).
As evidências atuais sugerem que há uma prevalência de 8-45% de envolvimento da mucosa oral em pacientes com LES (García-Ríos et al., 2022; Alrashdan et al., 2023) e varia significativamente por região, atividade da doença e entre os sexos (Du et al., 2023; Boodhoo et al., 2016).
As manifestações mais comuns incluem xerostomia, mucosite, glossite, queilite angular, ulceração da mucosa, pigmentação, glossodinia, língua fissurada, disgeusia, síndrome de Sjögren (García-Ríos et al., 2022; Stefanski et al., 2017), artrite, disfunção da articulação temporomandibular (óincoli et al., 2020) e aumento da incidência de cáries dentária, periodontite, gengivite e perda dentária (Aurlene et al., 2020; Hammoudeh et al., 2018).
Esta revisão visa identificar as manifestações orais associadas ao LES, que são consideradas como um estado generalizado pela OMS, de modo a facilitar o diagnóstico precoce, o tratamento e otimizar a gestão das complicações orais e assim melhorar a qualidade de vida dos pacientes (Saeed et al., 2022).
Metodologias
Assim pretende-se desenvolver uma revisão narrativa. O objetivo desta revisão é apresentar uma síntese qualitativa de estudos referentes as manifestações orais do lúpus eritematoso sistémico. Com base nisso, vamos realizar uma pesquisa de artigos nas bases de dados PubMed. Foram escolhidos artigos publicados entre 2014 e 2024 que analisaram as manifestações orais de pacientes com LES. Os artigos selecionados são revisão sistémica, Meta-analise, estudo clínico, estudo transversal e investigação.
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease (Leite et al., 2015) that affects between 12 and 50 per 100,000 people worldwide (Saccucci et al., 2018). This disease leads to tissue damage in multiple organs, including the kidneys, lungs, joints, heart, and brain (AlOmair et al., 2023; Graves et al., 2018). The etiology and pathogenesis of SLE are not well understood, making diagnosis and treatment selection difficult (García-Ríos et al., 2022). Current evidence suggests that oral mucosal involvement occurs in 8–45% of patients with SLE (García-Ríos et al., 2022; Alrashdan et al., 2023), with significant variations depending on region, disease activity, and sex (Du et al., 2023; Boodhoo et al., 2016). The most common manifestations include xerostomia, mucositis, glossitis, angular cheilitis, mucosal ulceration, pigmentation, glossodynia, fissured tongue, dysgeusia, Sjögren’s syndrome (García-Ríos et al., 2022; Stefanski et al., 2017), arthritis, temporomandibular joint dysfunction (Crincoli et al., 2020), and an increased incidence of dental caries, periodontitis, gingivitis, and tooth loss (Aurlene et al., 2020; Hammoudeh et al., 2018). This review aims to identify the oral manifestations associated with SLE, which are considered by the WHO as a generalized condition, in order to facilitate early diagnosis, treatment, and optimize the management of oral complications, thereby improving patients’ quality of life (Saeed et al., 2022). Methodology This work proposes to conduct a narrative review. The aim of this review is to present a qualitative synthesis of studies regarding the oral manifestations of systemic lupus erythematosus. Based on this, we will perform a search for articles in the PubMed database. Articles published between 2014 and 2024 that analyzed the oral manifestations of patients with SLE were selected. The included articles consist of systematic reviews, meta-analyses, clinical studies, cross-sectional studies, and research investigations.
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease (Leite et al., 2015) that affects between 12 and 50 per 100,000 people worldwide (Saccucci et al., 2018). This disease leads to tissue damage in multiple organs, including the kidneys, lungs, joints, heart, and brain (AlOmair et al., 2023; Graves et al., 2018). The etiology and pathogenesis of SLE are not well understood, making diagnosis and treatment selection difficult (García-Ríos et al., 2022). Current evidence suggests that oral mucosal involvement occurs in 8–45% of patients with SLE (García-Ríos et al., 2022; Alrashdan et al., 2023), with significant variations depending on region, disease activity, and sex (Du et al., 2023; Boodhoo et al., 2016). The most common manifestations include xerostomia, mucositis, glossitis, angular cheilitis, mucosal ulceration, pigmentation, glossodynia, fissured tongue, dysgeusia, Sjögren’s syndrome (García-Ríos et al., 2022; Stefanski et al., 2017), arthritis, temporomandibular joint dysfunction (Crincoli et al., 2020), and an increased incidence of dental caries, periodontitis, gingivitis, and tooth loss (Aurlene et al., 2020; Hammoudeh et al., 2018). This review aims to identify the oral manifestations associated with SLE, which are considered by the WHO as a generalized condition, in order to facilitate early diagnosis, treatment, and optimize the management of oral complications, thereby improving patients’ quality of life (Saeed et al., 2022). Methodology This work proposes to conduct a narrative review. The aim of this review is to present a qualitative synthesis of studies regarding the oral manifestations of systemic lupus erythematosus. Based on this, we will perform a search for articles in the PubMed database. Articles published between 2014 and 2024 that analyzed the oral manifestations of patients with SLE were selected. The included articles consist of systematic reviews, meta-analyses, clinical studies, cross-sectional studies, and research investigations.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Lúpus eritematoso sistêmico Manifestações orais