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Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy

2019-11Journal article Open access
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dc.contributor.authorMoranguinho, Inês
dc.contributor.authorBorrego, Pedro
dc.contributor.authorGonçalves, Fátima
dc.contributor.authorGomes, Perpétua
dc.contributor.authorRocha, José
dc.contributor.authorBarreto, Jorge
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2019-12-13T12:07:01Z
dc.date.available2021-12-31T01:30:22Z
dc.date.issued2019-11
dc.description.abstractThe pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationAIDS: November 14, 2019 - Volume Publish Ahead of Print. doi: 10.1097/QAD.0000000000002431pt_PT
dc.identifier.doi10.1097/QAD.0000000000002431pt_PT
dc.identifier.issn0269-9370
dc.identifier.issn1473-5571
dc.identifier.urihttp://hdl.handle.net/10400.26/30476
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwerpt_PT
dc.relation.publisherversionhttp://dx.doi.org//10.1097/QAD.0000000000002431pt_PT
dc.subjectHIV-2 infected patientspt_PT
dc.subjectGenotypic resistance profilespt_PT
dc.subjectCape Verdept_PT
dc.subjectAntiretroviral therapypt_PT
dc.titleGenotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAIDSpt_PT
rcaap.embargofctPolítica de copyright da editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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