Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy

Moranguinho, Inês; Borrego, Pedro; Gonçalves, Fátima; Gomes, Perpétua; Rocha, José; Barreto, Jorge; Taveira, Nuno

http://hdl.handle.net/10400.26/30476

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Abstract(s)

The pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.