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Efeitos da utilização a longo prazo de inibidores da bomba de protões
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Advisor(s)
Abstract(s)
Os inibidores da bomba de protões (IBP) são fármacos muito importantes para o tratamento de diversas patologias gástricas, entre elas a dispepsia, a doença do refluxo gastroesofágico (DRGE), o esófago de Barrett (EB), a infeção por Helicobacter pylori (HP), a pirose, a síndrome de Zollinger-Ellison (SZE) e as úlceras pépticas (gástricas e duodenais).
Em Portugal, os IBP assumem funções como modificadores de secreção gástrica, sendo que as principais substâncias ativas são o omeprazol, o lansoprazol, o pantoprazol, o rabeprazol, o esomeprazol e o dexlansoprazol. No que diz respeito aos efeitos adversos da utilização de longo prazo dos IBP, conclui-se que são vários os efeitos adversos e os quais os médicos devem ter em linha de conta quando prescrevem IBP.
Os IBP implicam múltiplos efeitos para a saúde do indivíduo, sendo de destacar: as infeções, nomeadamente a infeção por Clostridium difficile; as alterações na absorção de vitaminas e minerais, como a deficiência de vitamina B12, fraturas (défice de absorção de cálcio e risco de osteoporose), a doença renal crónica, hipergastrinemia, a hipomagnesemia, pneumonia adquirida na comunidade, demência, síndrome coronária aguda e a hipersecreção ácida rebound.
Pronton pump inhibitors (PPI) are very important drugs for the treatment of various gastric diseases, among them dyspepsia, gastroesophageal reflux disese (GERD), Barrett’s esophagus (BE), Helicobacter pylori infection (HPI), heartburn, Zollinger-Ellison syndrome (ZES) and peptic ulcers (gastric and duodenal). In Portugal, PPI assume functions as gastric acid suppressants, with the main active substances being omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole and dexlansoprazole. Regarding the adverse effects of long-term use of PPI, it is concluded that there are several adverse effects and which physicians should take into account when prescribing PPI. The PPI implicate multiple effects on the individual's health, such as infections, Clostridium difficile infection, changes in absorption, vitamin B12 deficiency, fractures (calcium absorption deficit and risk of osteoporosis), chronic kidney disease (CKD), hypergastreminia, hypomagnesemia, community-acquired pneumonia (CAP), dementia, acute coronary syndrome and rebound acid hypersecretion.
Pronton pump inhibitors (PPI) are very important drugs for the treatment of various gastric diseases, among them dyspepsia, gastroesophageal reflux disese (GERD), Barrett’s esophagus (BE), Helicobacter pylori infection (HPI), heartburn, Zollinger-Ellison syndrome (ZES) and peptic ulcers (gastric and duodenal). In Portugal, PPI assume functions as gastric acid suppressants, with the main active substances being omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole and dexlansoprazole. Regarding the adverse effects of long-term use of PPI, it is concluded that there are several adverse effects and which physicians should take into account when prescribing PPI. The PPI implicate multiple effects on the individual's health, such as infections, Clostridium difficile infection, changes in absorption, vitamin B12 deficiency, fractures (calcium absorption deficit and risk of osteoporosis), chronic kidney disease (CKD), hypergastreminia, hypomagnesemia, community-acquired pneumonia (CAP), dementia, acute coronary syndrome and rebound acid hypersecretion.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Inibidores da bomba de protões Efeitos adversos Utilização a longo prazo dos IBP