Publication
Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
| dc.contributor.author | Rocha, Cheila | |
| dc.contributor.author | Duarte, Joana | |
| dc.contributor.author | Borrego, Pedro | |
| dc.contributor.author | Calado, Rita | |
| dc.contributor.author | Marcelino, José Maria | |
| dc.contributor.author | Tendeiro, Rita | |
| dc.contributor.author | Valadas, Emília | |
| dc.contributor.author | Sousa, Ana Espada | |
| dc.contributor.author | Taveira, Nuno | |
| dc.date.accessioned | 2019-12-12T16:08:57Z | |
| dc.date.available | 2019-12-12T16:08:57Z | |
| dc.date.issued | 2017-11 | |
| dc.description.abstract | Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | AIDS: November 13, 2017 - Volume 31 - Issue 17 - p 2431–2433. doi: 10.1097/QAD.0000000000001661 | pt_PT |
| dc.identifier.doi | 10.1097/QAD.0000000000001661 | pt_PT |
| dc.identifier.issn | 0269-9370 | |
| dc.identifier.issn | 1473-5571 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/30469 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wolters Kluwer | pt_PT |
| dc.relation.publisherversion | http://dx.doi.org//10.1097/QAD.0000000000001661 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | HIV-2 antibodies | pt_PT |
| dc.subject | Memory B cells | pt_PT |
| dc.title | Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 2433 | pt_PT |
| oaire.citation.startPage | 2431 | pt_PT |
| oaire.citation.title | AIDS | pt_PT |
| oaire.citation.volume | 31(17) | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |