Name: | Description: | Size: | Format: | |
---|---|---|---|---|
166.89 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
Description
Keywords
HIV-2 antibodies Memory B cells
Citation
AIDS: November 13, 2017 - Volume 31 - Issue 17 - p 2431–2433. doi: 10.1097/QAD.0000000000001661
Publisher
Wolters Kluwer