Publicação
Non-surgical periodontal therapy’s influence on alpha-synuclein and inflammatory marker levels : a pilot study
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Lyra, Patrícia | |
| dc.contributor.author | Botelho, João | |
| dc.contributor.author | Rota, Sílvia | |
| dc.contributor.author | Poplawska-Domaszewicz, Karolina | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Guerreiro, Daniela | |
| dc.contributor.author | Proença, Luís | |
| dc.contributor.author | Barroso, Helena | |
| dc.contributor.author | Mendes, José João | |
| dc.contributor.author | Chaudhuri, Kallol Ray | |
| dc.date.accessioned | 2026-04-13T09:58:32Z | |
| dc.date.available | 2026-04-13T09:58:32Z | |
| dc.date.issued | 2024-06 | |
| dc.description.abstract | Background: Microbial dysbiosis may contribute to alpha-synuclein (α-Syn) homeostasis disruption, yet the burden of inflammatory periodontal infection and its treatment have never been studied in this regard. We aimed to compare the cytokine and α-Syn levels in the saliva and blood of patients with periodontitis who underwent non-surgical periodontal therapy (NSPT) and those of their healthy counterparts. Methods: Periodontal examination and saliva and blood sample collection were carried out in incoming patients at a university clinic. The periodontitis group (PG) received NSPT. The sample collection and periodontal observation were repeated 30 days after. IL-6, IL1-β and total α-Syn were quantified using immunoassay methods. The periodontal inflamed surface area (PISA) was calculated as a proxy for periodontal inflammation. Results: Eleven participants formed the PG, and there were fifteen healthy controls (HC). At baseline, no correlation between salivary and plasma α-Syn was found. The salivary α-Syn levels revealed a tendency to decrease 30 days after, particularly in the PD cases. The variation in PISA and α-Syn showed significant correlation. Salivary α-Syn correlated negatively with salivary IL-6 levels at both timepoints in the total sample (rho = −0.394 and rho = −0.451) and in the HC (rho = −0.632 and rho = −0.561). Variations in plasma IL-6 and α-Syn were negatively correlated (rho = −0.518) in the healthy participants. Baseline plasma IL1-β negatively correlated with plasmatic α-Syn at 30 days in the HC (rho = −0.581). Conclusions: Salivary and plasma α-Syn bioavailability operate independently, and periodontal diagnosis was not a confounding factor. Salivary α-Syn levels were significantly affected by NSPT, contrary to plasma levels. These results should be confirmed in future larger and prospective studies. | eng |
| dc.identifier.citation | Lyra P, Botelho J, Rota S, Poplawska-Domaszewicz K, Machado V, Guerreiro D, Proença L, Barroso H, Mendes JJ, Chaudhuri KR. Non-Surgical Periodontal Therapy’s Influence on Alpha-Synuclein and Inflammatory Marker Levels: A Pilot Study. Journal of Clinical Medicine. 2024; 13(12):3586. https://doi.org/10.3390/jcm13123586 | |
| dc.identifier.doi | 10.3390/jcm13123586 | |
| dc.identifier.issn | 2077-0383 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62652 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/jcm13123586 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | alpha-synuclein | |
| dc.subject | cytokines | |
| dc.subject | periodontitis | |
| dc.subject | periodontal disease | |
| dc.subject | oral health | |
| dc.subject | periodontal treatment | |
| dc.subject | inflammatory burden | |
| dc.title | Non-surgical periodontal therapy’s influence on alpha-synuclein and inflammatory marker levels : a pilot study | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 12 | |
| oaire.citation.startPage | 3586 | |
| oaire.citation.title | Journal of Clinical Medicine | |
| oaire.citation.volume | 13 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |