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Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease

2016-09-09Journal article Open access
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dc.contributor.authorPereira, A
dc.contributor.authorPalma dos Reis, R
dc.contributor.authorRodrigues, R
dc.contributor.authorSousa, A C
dc.contributor.authorGomes, S
dc.contributor.authorBorges, S
dc.contributor.authorOrnelas, I
dc.contributor.authorFreitas, A I
dc.contributor.authorGuerra, G
dc.contributor.authorHenriques, E
dc.contributor.authorRodrigues, M
dc.contributor.authorFreitas, S
dc.contributor.authorFreitas, C
dc.contributor.authorBrehm, A
dc.contributor.authorPereira, D
dc.contributor.authorMendonça, M I
dc.date.accessioned2019-03-11T12:00:45Z
dc.date.available2019-03-11T12:00:45Z
dc.date.issued2016-09-09
dc.description.abstractRecent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and vascular smooth muscular cell (VSMC) migration. Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD. A cohort of 1,128 patients with angiographic proven CAD, who were followed up prospectively for a mean follow-up period of 63 (range 6-182) mo, were genotyped for rs3825807 A/G. Survival statistics (Cox regression) compared heterozygous (AG) and wild-type (AA) with the reference homozygous GG. Kaplan-Meier (K-M) survival curves were performed according to ADAMTS7 genotypes for CV mortality. Results showed that 47.3% of patients were heterozygous (AG), 36.5% were homozygous for the wild-type allele (AA) and only 16.2% were homozygous for the GG genotype. During the follow-up period, 109 (9.7%) patients died, 77 (6.8%) of CV causes. Survival analysis showed that AA genotype was an independent risk factor for CV mortality compared with reference genotype GG (HR = 2.7, P = 0.025). At the end of follow-up, the estimated survival probability (K-M) was 89.8% for GG genotype, 82.2% for AG and 72.3% for AA genotype (P = 0.039). Carriage of the mutant G allele of the ADAMTS7 gene was associated with improved CV survival in patients with documented CAD. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events. ADAMTS7 gene should be further explored in CAD for risk prediction, mechanistic and therapeutic goals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira A, Palma Dos Reis R, Rodrigues R, Sousa AC, Gomes S, Borges S, Ornelas I, Freitas AI, Guerra G, Henriques E, Rodrigues M, Freitas S, Freitas C, Brehm A, Pereira D, Mendonca MI. Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease. Physiol Genomics. 2016;48:810–815.pt_PT
dc.identifier.doi10.1152/physiolgenomics.00059.2016pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/28044
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Physiological Societypt_PT
dc.subjectADAMTS7 genept_PT
dc.subjectCoronary Artery Diseasept_PT
dc.subjectPolymorphism, Single Nucleotidept_PT
dc.subjectSurvival Analysispt_PT
dc.subjectGenetic Association Studiespt_PT
dc.subjectGenetic Predisposition to Diseasept_PT
dc.subjectCardiovascular Survivalpt_PT
dc.subjectPortugalpt_PT
dc.subjectMadeirapt_PT
dc.titleAssociation of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage815pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage810pt_PT
oaire.citation.volume48pt_PT
person.familyNamepereira
person.familyNameReis
person.familyNameSousa
person.familyNameBorges
person.familyNameHenriques
person.familyNameRodrigues
person.familyNameFreitas
person.familyNameMendonca
person.givenNameandreia
person.givenNameRoberto
person.givenNameAna Célia
person.givenNameSofia
person.givenNameEva
person.givenNameMariana Rodrigues
person.givenNameSónia
person.givenNameMaria Isabel
person.identifier.orcid0000-0001-5129-2478
person.identifier.orcid0000-0003-2803-8193
person.identifier.orcid0000-0002-2069-0278
person.identifier.orcid0000-0002-9413-7942
person.identifier.orcid0000-0002-7312-5272
person.identifier.orcid0000-0001-7280-0021
person.identifier.orcid0000-0001-5204-8928
person.identifier.orcid0000-0001-5450-5213
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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SESARAM - C - Unidade de Investigação Dr.ª Maria Isabel Mendonça