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  • Search for Higgs and $Z$ Boson Decays to $\phi\,\gamma$ with the ATLAS Detector
    Publication . ATLAS collaboration (2859 authors); Aguilar-Saavedra, Juan Antonio; Amor Dos Santos, Susana Patricia; Anjos, Nuno; Araque, Juan Pedro; Cantrill, Robert; Carvalho, João; Castro, Nuno Filipe; Conde Muiño, Patricia; Da Cunha Sargedas De Sousa, Mario Jose; Fiolhais, Miguel; Galhardo, Bruno; Gomes, Agostinho; Gonçalo, Ricardo; Jorge, Pedro; Lopes, Lourenco; Machado Miguens, Joana; Maio, Amélia; Maneira, José; Oleiro Seabra, Luis Filipe; Onofre, António; Pedro, Rute; Santos, Helena; Saraiva, João; Silva, José; Tavares Delgado, Ademar; Veloso, Filipe; Wolters, Helmut
    A search for the decays of the Higgs and Z bosons to a ϕ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of 2.7  fb-1 collected at s=13  TeV with the ATLAS detector at the LHC. No significant excess of events is observed above the background, and 95% confidence level upper limits on the branching fractions of the Higgs and Z boson decays to ϕγ of 1.4×10-3 and 8.3×10-6, respectively, are obtained.
    2016-09-09Journal article Open access Show more
  • Search for Higgs boson off-shell production in proton-proton collisions at 7 and 8 TeV and derivation of constraints on its total decay width
    Publication . CMS collaboration (2299 authors); Calpas, Betty; Nayak, Aruna; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nguyen, Federico; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; David Tinoco Mendes, Andre; Silva, Pedro; Musella, Pasquale; Pela, Joao
    A search is presented for the Higgs boson off-shell production in gluon fusion and vector boson fusion processes with the Higgs boson decaying into a W$^{+}$W$^{−}$ pair and the W bosons decaying leptonically. The data observed in this analysis are used to constrain the Higgs boson total decay width. The analysis is based on the data collected by the CMS experiment at the LHC, corresponding to integrated luminosities of 4.9 fb$^{−1}$ at a centre-of-mass energy of 7 TeV and 19.4 fb$^{−1}$ at 8 TeV, respectively. An observed (expected) upper limit on the off-shell Higgs boson event yield normalised to the standard model prediction of 2.4 (6.2) is obtained at the 95% CL for the gluon fusion process and of 19.3 (34.4) for the vector boson fusion process. Observed and expected limits on the total width of 26 and 66 MeV are found, respectively, at the 95% confidence level (CL). These limits are combined with the previous result in the ZZ channel leading to observed and expected 95% CL upper limits on the width of 13 and 26 MeV, respectively.
    2016-09-09Journal article Open access Show more
  • Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
    Publication . Pereira, A; Palma dos Reis, R; Rodrigues, R; Sousa, A C; Gomes, S; Borges, S; Ornelas, I; Freitas, A I; Guerra, G; Henriques, E; Rodrigues, M; Freitas, S; Freitas, C; Brehm, A; Pereira, D; Mendonça, M I
    Recent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and vascular smooth muscular cell (VSMC) migration. Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD. A cohort of 1,128 patients with angiographic proven CAD, who were followed up prospectively for a mean follow-up period of 63 (range 6-182) mo, were genotyped for rs3825807 A/G. Survival statistics (Cox regression) compared heterozygous (AG) and wild-type (AA) with the reference homozygous GG. Kaplan-Meier (K-M) survival curves were performed according to ADAMTS7 genotypes for CV mortality. Results showed that 47.3% of patients were heterozygous (AG), 36.5% were homozygous for the wild-type allele (AA) and only 16.2% were homozygous for the GG genotype. During the follow-up period, 109 (9.7%) patients died, 77 (6.8%) of CV causes. Survival analysis showed that AA genotype was an independent risk factor for CV mortality compared with reference genotype GG (HR = 2.7, P = 0.025). At the end of follow-up, the estimated survival probability (K-M) was 89.8% for GG genotype, 82.2% for AG and 72.3% for AA genotype (P = 0.039). Carriage of the mutant G allele of the ADAMTS7 gene was associated with improved CV survival in patients with documented CAD. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events. ADAMTS7 gene should be further explored in CAD for risk prediction, mechanistic and therapeutic goals.
    2016-09-09Journal article Open access Show more