Publication
Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
| dc.contributor.author | Valente Aguiar, P | |
| dc.contributor.author | Sousa, O | |
| dc.contributor.author | Silva, R | |
| dc.contributor.author | Vaz, R | |
| dc.contributor.author | Linhares, P | |
| dc.date.accessioned | 2023-01-31T23:06:51Z | |
| dc.date.available | 2023-01-31T23:06:51Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Neurocirugia (Astur : Engl Ed) . 2022 Jan-Feb;33(1):31-34. | pt_PT |
| dc.identifier.doi | 10.1016/j.neucie.2020.09.001 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/43496 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Astrocitoma | pt_PT |
| dc.subject | Astrocytoma | pt_PT |
| dc.title | Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 34 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 31 | pt_PT |
| oaire.citation.title | Neurocirugía (English Edition) | pt_PT |
| oaire.citation.volume | 33 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |