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Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
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Orientador(es)
Resumo(s)
Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.
Descrição
Palavras-chave
Astrocitoma Astrocytoma
Contexto Educativo
Citação
Neurocirugia (Astur : Engl Ed) . 2022 Jan-Feb;33(1):31-34.