Loading...
Publication
Utilização de biomarcadores salivares para o diagnóstico precoce do cancro oral
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 2.68 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Atualmente, o cancro oral afecta mais de 370 000 novos casos por ano em todo o mundo e a sua taxa de sobrevivência aos cinco anos continua a ser relativamente baixa: menos de 50%.
No entanto, a taxa de cura é significativamente mais elevada quando a doença é diagnosticada numa fase inicial. Esta elevada taxa de mortalidade do cancro oral resulta, de facto, do facto de a doença ser frequentemente diagnosticada tardiamente. Por conseguinte, parece necessário desenvolver novos métodos de diagnóstico fiáveis, rápidos, fáceis de utilizar e pouco dispendiosos, a fim de permitir o diagnóstico precoce
da doença.
Uma abordagem interessante, que já foi objeto de vários estudos, é a utilização de biomarcadores salivares específicos. A longo prazo, estes poderiam levar ao desenvolvimento de testes salivares de diagnóstico rápido.
Foi realizada uma pesquisa bibliográfica de artigos científicos recorrendo a PubMed, Google Scholar, e Cochrane com o objetivo de realizar uma revisão narrativa sobre a possível existência de biomarcadores salivares específicos do cancro oral e da sua possível utilização como ferramentas de diagnóstico precoce.
Oral cancer currently affects more than 370,000 new cases worldwide every year, and its five-year survival rate remains relatively low: less than 50%. Yet the cure rate is significantly higher when the disease is diagnosed at an early stage. This high mortality rate from oral cancer is in fact the result of the disease often being diagnosed late. It therefore seems necessary to develop new diagnostic methods that are reliable, rapid, easy to use and inexpensive, in order to enable early diagnosis of the disease. One interesting approach, which has already been the subject of several studies, is the use of specific salivary biomarkers. In the long term, these could lead to the development of rapid salivary diagnostic tests. A search for scientific articles was carried out using the Pubmed, Google Scholar and Cochrane databases, with the aim of producing a narrative review on the possible existence of salivary biomarkers specific to oral cancer and their possible use as an early diagnosis tool.
Oral cancer currently affects more than 370,000 new cases worldwide every year, and its five-year survival rate remains relatively low: less than 50%. Yet the cure rate is significantly higher when the disease is diagnosed at an early stage. This high mortality rate from oral cancer is in fact the result of the disease often being diagnosed late. It therefore seems necessary to develop new diagnostic methods that are reliable, rapid, easy to use and inexpensive, in order to enable early diagnosis of the disease. One interesting approach, which has already been the subject of several studies, is the use of specific salivary biomarkers. In the long term, these could lead to the development of rapid salivary diagnostic tests. A search for scientific articles was carried out using the Pubmed, Google Scholar and Cochrane databases, with the aim of producing a narrative review on the possible existence of salivary biomarkers specific to oral cancer and their possible use as an early diagnosis tool.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Cancro oral Diagnóstico oral Saliva Biomarcadores