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Clinical, endoscopic and histologic differences in gastric mucosa between younger and older adults : an observational study on the aging stomach

2025-10Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorVara-Luiz, Francisco
dc.contributor.authorMendes, Ivo
dc.contributor.authorPalma, Carolina
dc.contributor.authorMascarenhas, Paulo
dc.contributor.authorTeles, Ana Elisa
dc.contributor.authorSantos, Inês Costa
dc.contributor.authorNunes, Gonçalo
dc.contributor.authorPatita, Marta
dc.contributor.authorMocanu, Irina
dc.contributor.authorPires, Sara
dc.contributor.authorMeira, Tânia
dc.contributor.authorVieira, Ana
dc.contributor.authorPinto-Marques, Pedro
dc.contributor.authorGomes-Pinto, Daniel
dc.contributor.authorFonseca, Jorge
dc.date.accessioned2026-04-29T15:04:46Z
dc.date.available2026-04-29T15:04:46Z
dc.date.issued2025-10
dc.description.abstractBackground/Objectives: Age-related changes in the gastric mucosa remain incompletely understood. We aimed to assess and compare clinical, endoscopic and histologic changes in the gastric mucosa associated with aging, and to explore whether gastric aging is associated with a distinct histological pattern. Methods: Single-center observational study. Younger (18–45 years) and older (≥70 years) adults undergoing elective upper endoscopy were included and underwent gastric biopsies. The clinical, endoscopic and histologic features were analyzed and compared. Results: A total of 100 patients were included (45 men/55 women), 50 with 18–45 years and 50 with ≥70 years. Dyspepsia, gastro-esophageal reflux disease and peptic ulcer disease were the most common indications for upper endoscopy. Gastric lesions (erythema, erosions, ulceration and polyps) were more common in older patients (80% vs. 50%, p = 0.003), as well as histologic changes such as chronic gastritis (56% vs. 38%, p = 0.004), chronic atrophic gastritis (CAG; 28% vs. 4%, p < 0.001) and intestinal metaplasia (28% vs. 4%, p < 0.001). These findings persisted after adjusting for Helicobacter pylori (H. pylori) status and proton pump inhibitor intake on the multivariate analysis. Prevalence of H. pylori was similar between both groups (28% vs. 32%, p = 0.189). Conclusions: Aging is associated with clinical, endoscopic and histologic changes in the gastric mucosa including CAG and metaplasia, independent of the presence of H. pylori. These findings may result from several aging-related pathophysiological processes and decades of cumulative gastric injury and support the hypothesis of an aging stomach phenotype, underscoring the need for an age-adjusted interpretation of gastric biopsies.eng
dc.identifier.citationVara-Luiz F, Mendes I, Palma C, Mascarenhas P, Teles AE, Santos IC, Nunes G, Patita M, Mocanu I, Pires S, et al. Clinical, Endoscopic and Histologic Differences in Gastric Mucosa Between Younger and Older Adults: An Observational Study on the Aging Stomach. Medical Sciences. 2025; 13(4):224. https://doi.org/10.3390/medsci13040224
dc.identifier.doi10.3390/medsci13040224
dc.identifier.issn2076-3271
dc.identifier.urihttp://hdl.handle.net/10400.26/62953
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/medsci13040224
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaging
dc.subjectchronic gastritis
dc.subjectintestinal metaplasia
dc.subjectatrophic gastritis
dc.subjectHelicobacter pylori
dc.titleClinical, endoscopic and histologic differences in gastric mucosa between younger and older adults : an observational study on the aging stomacheng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.startPage224
oaire.citation.titleMedical Sciences
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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