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Association between periodontitis and peripheral markers of innate immunity activation and inflammation

2023-01Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorDopico, José
dc.contributor.authorBotelho, João
dc.contributor.authorOuro, Alberto
dc.contributor.authorDomínguez, Clara
dc.contributor.authorMachado, Vanessa
dc.contributor.authorAramburu-Nuñez, Marta
dc.contributor.authorCustodia, Antía
dc.contributor.authorBlanco, Teresa
dc.contributor.authorVázquez-Reza, María
dc.contributor.authorRomaus-Sanjurjo, Daniel
dc.contributor.authorBlanco, Juan
dc.contributor.authorLeira, Rogelio
dc.contributor.authorSobrino, Tomás
dc.contributor.authorLeira, Yago
dc.date.accessioned2025-12-22T15:10:58Z
dc.date.available2025-12-22T15:10:58Z
dc.date.issued2023-01
dc.description.abstractBackground: Immune response leading to increased systemic inflammation is one of the mechanisms linking periodontitis to chronic inflammatory diseases. The aim of this study was to compare the expression of toll-like receptors 2 and 4 in monocytes and neutrophils (TLR2M, TLR2N, TLR4M, and TLR4N) and its endogenous ligands (cellular fibronectin [cFN] and heat shock protein 60 [HSP60]) in patients with and without periodontitis. Additionally, the relationship between cFN and HSP60 expression with innate immunity activation and systemic inflammatory response (interleukin 6 [IL-6]) was also evaluated. Methods: A case-controlled study was designed in which 30 patients with periodontitis (cases) and 30 age- and sex-matched participants without periodontitis (controls) were included. Fasting blood samples were collected to determine: (1) expression of TLR2N, TLR2M, TLR4N, and TLR4M by flow cytometry; and (2) serum concentrations of cFN, HSP60, and IL-6 by ELISA technique. Results: Expression of TLR2M (411.5 [314.2, 460.0] vs. 236.5 [204.0, 333.0] AFU), TLR2N (387.0 [332.0, 545.5] vs 230.0 [166.2, 277.7] AFU), TLR4M (2478.5 [1762.2, 2828.0] vs 1705.0 [1274.5, 1951.2] AFU), and TLR4N (2791.0 [2306.7, 3226.2] vs. 1866.0 [1547.5, 2687.2] AFU) as well as serum levels of cFN (301.1 [222.2, 410.9] vs. 156.4 [115.3, 194.0] ng/ml) and IL-6 (10.4 [6.5, 11.5] vs. 3.5 [2.6, 4.9] pg/ml) were significantly higher in periodontitis patients than those without periodontitis. A positive association was found between periodontitis and cFN (odds ratio [OR] = 1.028, p < 0.001), TLR2N (OR = 1.026, p < 0.001), TLR4M (OR = 1.001, p = 0.002), and IL-6 (OR = 1.774, p < 0.001). Conclusions: Periodontitis patients exhibited high expression of TLRs, cFN, and IL-6.eng
dc.identifier.citationDopico J, Botelho J, Ouro A, et al. Association between periodontitis and peripheral markers of innate immunity activation and inflammation. J Periodontol. 2023; 94: 11–19. https://doi.org/10.1002/JPER.22-0216
dc.identifier.doi10.1002/JPER.22-0216
dc.identifier.issn1943-3670
dc.identifier.urihttp://hdl.handle.net/10400.26/60542
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://doi.org/10.1002/JPER.22-0216
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectfibronectin
dc.subjectinflammation
dc.subjectinnate immunity
dc.subjectperiodontitis
dc.subjecttoll-like receptor
dc.titleAssociation between periodontitis and peripheral markers of innate immunity activation and inflammationeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.endPage19
oaire.citation.issue1
oaire.citation.startPage11
oaire.citation.titleJournal of Periodontology
oaire.citation.volume94
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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