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Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

2016-12Journal article Open access
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dc.contributor.authorPimenta, A. F. R.
dc.contributor.authorValente, A.
dc.contributor.authorPereira, J. M. C.
dc.contributor.authorPereira, J. C. F.
dc.contributor.authorFilipe, H. P.
dc.contributor.authorMata, J. L. G.
dc.contributor.authorColaço, R.
dc.contributor.authorSaramago, B.
dc.contributor.authorSerro, A. P.
dc.date.accessioned2018-01-10T15:38:49Z
dc.date.available2018-01-10T15:38:49Z
dc.date.issued2016-12
dc.descriptionThe final publication is available at Springer via http://dx.doi.org/10.1007/s13346-016-0303-1pt_PT
dc.description.abstractCurrently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo. In this work, a microfluidic cell was designed and used to mimic the continuous, volumetric flow rate of tear fluid and its low volume. The suitable operation of the cell, in terms of uniformity and symmetry of flux, was proved using a numerical model based in the Navier-Stokes and continuity equations. The release profile of a model system (a hydroxyethyl methacrylate-based hydrogel (HEMA/PVP) for soft contact lenses (SCLs) loaded with diclofenac) obtained with the microfluidic cell was compared with that obtained in static conditions, showing that the kinetics of release in dynamic conditions is slower. The application of the numerical model demonstrated that the designed cell can be used to simulate the drug release in the whole range of the human eye tear film volume and allowed to estimate the drug concentration in the volume of liquid in direct contact with the hydrogel. The knowledge of this concentration, which is significantly different from that measured in the experimental tests during the first hours of release, is critical to predict the toxicity of the drug release system and its in vivo efficacy. In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug-loaded SCLs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPimenta, A.F.R., Valente, A., Pereira, J.M.C. et al. Drug Deliv. and Transl. Res. (2016) 6: 755. https://doi.org/10.1007/s13346-016-0303-1pt_PT
dc.identifier.doi10.1007/s13346-016-0303-1pt_PT
dc.identifier.issn2190-393X
dc.identifier.issn2190-3948
dc.identifier.urihttp://hdl.handle.net/10400.26/20049
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationSURFACE MODIFICATIONS TO CONTROL DRUG RELEASE FROM THERAPEUTIC OPHTHALMIC LENSES
dc.relation.publisherversionhttps://dx.doi.org/10.1007/s13346-016-0303-1pt_PT
dc.subjectControlled drug releasept_PT
dc.subjectHydrogelspt_PT
dc.subjectContact lensespt_PT
dc.subjectMicrofluidicspt_PT
dc.subjectNumerical simulationpt_PT
dc.titleSimulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modelingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSURFACE MODIFICATIONS TO CONTROL DRUG RELEASE FROM THERAPEUTIC OPHTHALMIC LENSES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FQUI%2FUI0100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEMS%2F50022%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F52334%2F2013/PT
oaire.citation.endPage762pt_PT
oaire.citation.startPage755pt_PT
oaire.citation.titleDrug Delivery and Translational Researchpt_PT
oaire.citation.volume6(6)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication09b9027b-a82d-4ab5-bd50-3b94fecdc5e9
relation.isProjectOfPublicationbf1cd7d5-a9c0-4159-91e5-1d72d8d3cf81
relation.isProjectOfPublication8632269b-8e4b-4355-a5ed-db05c16d8002
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