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Eficácia dos sialogogos tópicos no tratamento de xerostomia em residentes crónicos do C.H.P.L.
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Abstract(s)
Introdução: Pacientes institucionalizados com doenças psiquiátricas provocadas por disfunções do sistema nervoso central são mais propensos a desenvolver doenças orais. O uso prolongado de fármacos xerogénicos têm como efeitos colaterais, uma alteração fisiológica das glândulas salivares e subsequentemente a xerostomia. Deste modo, pode resultar num impacto negativo na qualidade de vida relacionada com a saúde oral dos pacientes.
Objetivos: Descrever a prevalência, determinar a gravidade e autoperceção da Xerostomia nos pacientes crónicos residentes no C.H.P.L. e avaliar a eficácia dos sialogogos tópicos no tratamento da Xerostomia.
Materiais e Métodos: Uma amostra de 81 pacientes residentes no C.H.P.L., consentiu a participação no estudo. Aprovado pela Comissão de Ética do Centro Hospitalar Psiquiátrico de Lisboa e do Egas Moniz (nº1197). Foi aplicado um questionário composto por variáveis sociodemográficas, dados referentes às patologias psiquiátricas e a respetiva medicação, Summated Xerostomy Inventory (SXI-PL). Aplicou-se a sialometria para recolha das taxas de fluxo salivar não estimulado (TFSNE) e estimulado (TFSE) e a Saliva Check-Buffer, em 2 tempos (T0 e T1) com espaço de 15 dias. Durante este período administrou-se o sialagogo tópico Xeros Dentaid Gel ®, composto por betaína (1%), aloé vera (0,05%), xilitol (10%) e fluoreto de sódio (0,0033%). Os dados recolhidos foram submetidos a análise estatística através do SPSS®.
Resultados: A média da faixa etária é de 47,83, sendo o género masculino predominante (81,5%). A prevalência de Xerostomia diminui após aplicação do tratamento com o sialogogo tópico para 7,4%. Relativamente às TFSNE e TFSE podemos verificar que existiu um aumento significativo de 0,28 ml/min e 0,15 ml/min, respetivamente. Os valores de pH obtiveram um aumento significativo contrariamente à capacidade tampão que se manteve igual após o tratamento.
Conclusão: A administração do sialagogo tópico num período de 15 dias demonstrou eficácia no aumento das TFSNE e TFSE, como, no pH da saliva.
Introduction: Institutionalized patients with psychiatric illnesses caused by central nervous system dysfunctions are more likely to develop oral diseases. Prolonged use of xerogenic drugs has the side effect of physiologically altering the salivary glands and subsequently causing xerostomia. This can have a negative impact on patients' oral health-related quality of life. Objectives: To describe the prevalence, determine the severity and self-perception of Xerostomia in chronic patients living at the C.H.P.L. and evaluate the efficacy of topical sialogogues in the treatment of Xerostomia. Materials and Methods: A sample of 81 patients living at the C.H.P.L. consented to take part in the study. The study was approved by the Ethics Committee of the Centro Hospitalar Psiquiátrico de Lisboa and Egas Moniz (nº1197). A questionnaire comprising sociodemographic variables, data on psychiatric conditions and medication, and the Summated Xerostomy Inventory (SXI-PL) was administered. Sialometry was applied to collect unstimulated (TFSNE) and stimulated (TFSE) salivary flow rates and the Saliva Check-Buffer, at 2 timelines (T0 and T1), 15 days apart. During this period, was administered a topical sialagogue Xeros Dentaid Gel ®, consisting of betaine (1%), aloe vera (0.05%), xylitol (10%) and sodium fluoride (0.0033%). All data collected was subjected to statistical analysis using SPSS®. Results: The average age was 47.83 and males predominated (81.5%). The prevalence of xerostomia decreased after topical sialogogue treatment to 7.4%. Regarding TFSNE and TFSE, there’s improvement in both salivary flow rates with a significant increase of 0.28 ml/min and 0.15 ml/min, respectively. The pH values increased significantly, unlike the buffer capacity, which remained the same after treatment. Conclusion: The administration of topical sialagogue over a period of 15 days proved effective in increasing TFSNE and TFSE, as well as saliva pH.
Introduction: Institutionalized patients with psychiatric illnesses caused by central nervous system dysfunctions are more likely to develop oral diseases. Prolonged use of xerogenic drugs has the side effect of physiologically altering the salivary glands and subsequently causing xerostomia. This can have a negative impact on patients' oral health-related quality of life. Objectives: To describe the prevalence, determine the severity and self-perception of Xerostomia in chronic patients living at the C.H.P.L. and evaluate the efficacy of topical sialogogues in the treatment of Xerostomia. Materials and Methods: A sample of 81 patients living at the C.H.P.L. consented to take part in the study. The study was approved by the Ethics Committee of the Centro Hospitalar Psiquiátrico de Lisboa and Egas Moniz (nº1197). A questionnaire comprising sociodemographic variables, data on psychiatric conditions and medication, and the Summated Xerostomy Inventory (SXI-PL) was administered. Sialometry was applied to collect unstimulated (TFSNE) and stimulated (TFSE) salivary flow rates and the Saliva Check-Buffer, at 2 timelines (T0 and T1), 15 days apart. During this period, was administered a topical sialagogue Xeros Dentaid Gel ®, consisting of betaine (1%), aloe vera (0.05%), xylitol (10%) and sodium fluoride (0.0033%). All data collected was subjected to statistical analysis using SPSS®. Results: The average age was 47.83 and males predominated (81.5%). The prevalence of xerostomia decreased after topical sialogogue treatment to 7.4%. Regarding TFSNE and TFSE, there’s improvement in both salivary flow rates with a significant increase of 0.28 ml/min and 0.15 ml/min, respectively. The pH values increased significantly, unlike the buffer capacity, which remained the same after treatment. Conclusion: The administration of topical sialagogue over a period of 15 days proved effective in increasing TFSNE and TFSE, as well as saliva pH.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Xerostomia Polimedicação Patologia psiquiátrica Psicotrópicos