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Publication
Mecanismos moleculares na origem do cancro da próstata
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Abstract(s)
O cancro da próstata é o tipo de cancro mais comum nos homens no mundo. A identificação e compreensão dos mecanismos moleculares envolvidos no início e progressão deste cancro são a base para o desenvolvimento de terapêuticas com um potencial forte para terem uma acção mais eficaz.
Com esta revisão biliográfica tentou-se, mais especificamente, associar as alterações genéticas, cromossómicas, moleculares e celulares aos mecanismos celulares da carcinogénse do cancro da próstata.
Os conhecimentos destes conceitos são essenciais para a formulação e aperfeiçoamento de terapias-alvo a moléculas específicas ou vias celulares mais adequadas ao tratamento deste tipo de cancro.
Para a elaboração desta monografia, foram analisados cerca de 50 artigos entre 2013 e 2018, nas seguintes bases de dados: PubMed, Google Scholar.
Prostate cancer is the most common type of cancer in the world for men. The identification and compreehension of the molecular mechanisms underlying the beggining and progression of this cancer are the basis for the development of therapeutics with a strong potencial to have a more effective action. With this biliografic review it was tried, more specificaly, to associate the genetic, cromossomic, molecular, and celullar alterations to the molecular mechanisms involved in the carcinogenesis of prostate cancer. The knowledge of this concepts are essencial for the formulation and improvement of target-therapeutics to specific molecules or pathways more suited to treat this type of cancer. For the elaboration of this monography, about 50 articles were analyzed, between the years of 2013 and 2018, from the following data bases: PubMed, Google Scholar.
Prostate cancer is the most common type of cancer in the world for men. The identification and compreehension of the molecular mechanisms underlying the beggining and progression of this cancer are the basis for the development of therapeutics with a strong potencial to have a more effective action. With this biliografic review it was tried, more specificaly, to associate the genetic, cromossomic, molecular, and celullar alterations to the molecular mechanisms involved in the carcinogenesis of prostate cancer. The knowledge of this concepts are essencial for the formulation and improvement of target-therapeutics to specific molecules or pathways more suited to treat this type of cancer. For the elaboration of this monography, about 50 articles were analyzed, between the years of 2013 and 2018, from the following data bases: PubMed, Google Scholar.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Prostate cancer Molecular mechanisms Carcinogenesis