Logo do repositório
 
Publicação

Determinants of HIV-1 transmission clusters and transmitted drug resistance in men who have sex with men : a multicenter study in Portugal (2014-2019)

2025-06Contributo em revista Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAbrantes, Ricardo
dc.contributor.authorPimentel, Victor
dc.contributor.authorSebastião, Cruz
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorSeabra, Sofia
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorSilva, Elisabete Gomes da
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorDiogo, Isabel
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorCunha, José Saraiva da
dc.contributor.authorSoares, Jorge
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorAbreu, Ricardo Correia de
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorCastro, Rui Sarmento e
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorSimões, Daniel
dc.contributor.authorMendão, Luís
dc.contributor.authorMartins, M. Rosário O.
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorOn behalf of BESTHOPE Study Group
dc.date.accessioned2026-05-05T14:27:53Z
dc.date.available2026-05-05T14:27:53Z
dc.date.issued2025-06
dc.description.abstractIntroduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM newly diagnosed in Portugal between 2014 and 2019. Methods: A total of 340 MSM newly diagnosed with HIV-1 infection at 17 hospitals in Portugal were included. TC was identified with branch support ≥90% and 1.5% genetic distance. Logistic regression models were used to examine factors associated with TC and TDR. Results: We identified 38 TC with 104 MSM, which includes 81 (26.6%) of the 305 MSM from our sample included in cluster analysis. The overall prevalence of TDR was 8.2%. Only HIV-1 subtype C was significantly associated with TDR. Overall, 10.5% of the clusters had at least 1 surveillance drug resistance mutation. There was no significant difference in the prevalence of TDR or the proportion of Portuguese and migrant MSM inside and outside clusters. Age at diagnosis, district of residence, unprotected sex with a woman, HIV testing, presenter status, and HIV-1 subtype were significantly associated with TC. Conclusion: Specific subgroups of MSM are contributing to HIV-1 clustered transmission in Portugal. However, no association was found between TDR and sociodemographic or behavioral factors. Directed prevention measures should focus on those subgroups.eng
dc.identifier.citationAbrantes, R., Pimentel, V., Sebastião, C., Miranda, M. N. S., Seabra, S., Silva, A. R., Diniz, A., Ascenção, B., Piñeiro, C., Koch, C., Rodrigues, C., Caldas, C., Morais, C., Faria, D., da Silva, E. G., Teófilo, E., Monteiro, F., Roxo, F., Maltez, F., Rodrigues, F., … BESTHOPE Study Group (2025). Determinants of HIV-1 transmission clusters and transmitted drug resistance in men who have sex with men: A multicenter study in Portugal (2014-2019). International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 155, 107888. https://doi.org/10.1016/j.ijid.2025.107888
dc.identifier.doi10.1016/j.ijid.2025.107888
dc.identifier.issn1878-3511
dc.identifier.urihttp://hdl.handle.net/10400.26/62988
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://doi.org/10.1016/j.ijid.2025.107888
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV-1
dc.subjectTransmission cluster
dc.subjectdrug resistance
dc.subjectPortugal
dc.subjectMen who have sex with men
dc.titleDeterminants of HIV-1 transmission clusters and transmitted drug resistance in men who have sex with men : a multicenter study in Portugal (2014-2019)eng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage107888
oaire.citation.titleInternational Journal of Infectious Diseases
oaire.citation.volume155
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Artigo_PGomes_2025_01.pdf
Tamanho:
1.48 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.85 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

EM - Artigos Científicos